David C Blum

US Patent:

7297795, Nov 20, 2007

Filed:

Aug 16, 2004

Appl. No.:

10/918947

Inventors:

Karen Wiggins Sutherland - New City NY, US
Gregg Brian Feigelson - Chester NY, US
Diane Harris Boschelli - New City NY, US
David Michael Blum - Upper Saddle River NJ, US
Henry Lee Strong - Somerset NJ, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07D 215/44

US Classification:

546159, 546160

Abstract:

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.

US Patent:

7396835, Jul 8, 2008

Filed:

Dec 8, 2004

Appl. No.:

11/007839

Inventors:

Yanzhong Wu - Bronx NY, US
Jean Schmid - Chester NY, US
Jay Thomas Afragola - Spring Valley NY, US
David Blum - Saddle River NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A01N 43/90
A61K 31/519
C07D 487/00

US Classification:

51425931, 544263

Abstract:

The present invention provides a process for the preparation of 6-[(substituted)phenyl]-triazolopyrimidine dicarboxylic acid salt and as a hydrated salt having the structural formula (I).

US Patent:

7419982, Sep 2, 2008

Filed:

May 19, 2006

Appl. No.:

11/437291

Inventors:

Fang Fang Qi - New City NY, US
Mannching Sherry Ku - Thiells NY, US
Yanzhong Wu - Bardonia NY, US
David M. Blum - Upper Saddle River NJ, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A01N 43/90
A61K 31/519
C07D 487/00

US Classification:

51425931, 544263

Abstract:

The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions thereof; and methods for inhibiting tumor growth therewith.

US Patent:

7541485, Jun 2, 2009

Filed:

Jul 11, 2006

Appl. No.:

11/484217

Inventors:

Ronald S. Michalak - Congers NY, US
Joseph Zeldis - New City NY, US
Mel Jennings - Highland Falls NY, US
David M. Blum - Upper Saddle River NJ, US
Timothy Doyle - Morristown NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07C 237/02

US Classification:

558267, 562450

Abstract:

The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.

US Patent:

20070090073, Apr 26, 2007

Filed:

Oct 26, 2005

Appl. No.:

11/258118

Inventors:

David Blum - Stamford CT, US
Michael Blum - Ridgefield CT, US
Steven Lorraine - Glastonbury CT, US
John Gephart - Rocky Hill CT, US

Assignee:

THE STANLEY WORKS - New Britain CT

International Classification:

A47F 5/08

US Classification:

211094010

Abstract:

A system for exhibiting a sample of a product. The system comprises a rail and a display unit. The rail extends from a first end to a second end, and includes at least one display unit engaging portion. The display unit can be removably mounted on the rail, and has a display surface, formed on the front of the display unit, on which the sample of the product can be mounted. The display unit also has at least one rail engaging portion, the at least one rail engaging portion being removably engagable with the at least one display unit engaging portion. The display unit can be removably mounted on the rail directly at a predetermined location between the first end and the second end of the rail through a snap-fit connection between the at least one rail engaging portion and the at least one display unit engaging portion.

US Patent:

20070149499, Jun 28, 2007

Filed:

Aug 22, 2006

Appl. No.:

11/508037

Inventors:

Ronald Michalak - Congers NY, US
Rocco Galante - Oakland NJ, US
David Blum - Upper Saddle River NJ, US
Julianne Blum - Upper Saddle River NJ, US
Lisa Routel - Valley Cottage NY, US
Haris Durutlic - New Windsor NY, US
Charles Guinosso - Chestnut Ridge NY, US
John Considine - Bridgewater NJ, US
Kenneth Kremer - Lawrenceville NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/43
C07D 499/46

US Classification:

514196000, 548154000, 540329000

Abstract:

The present invention relates to processes for preparing β-alkylidene penem derivatives that can be important as broad spectrum β-lactamase inhibitors and anti-bacterial agents.

US Patent:

20080033175, Feb 7, 2008

Filed:

Oct 5, 2007

Appl. No.:

11/973259

Inventors:

Karen Sutherland - New City NY, US
Gregg Feigelson - Chester NY, US
Diane Boschelli - New City NY, US
David Blum - Upper Saddle River NJ, US
Henry Strong - Somerset NJ, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07D 401/00
C07D 471/02

US Classification:

544363000, 546114000

Abstract:

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.

US Patent:

45672040, Jan 28, 1986

Filed:

Jul 23, 1984

Appl. No.:

6/633231

Inventors:

R. Lawrence Mednick - Roslyn Heights NY
David B. Blum - Wayne NJ

Assignee:

Chem Systems, Inc. - Tarrytown NY

International Classification:

C07C 2916

US Classification:

518700

Abstract:

Methanol is made in a liquid-phase methanol reactor by entraining a methanol-forming catalyst in an inert liquid and contacting said entrained catalyst with a synthesis gas comprising hydrogen and carbon monoxide.