David Richard Blum

US Patent:

8426184, Apr 23, 2013

Filed:

Jan 13, 2006

Appl. No.:

11/908672

Inventors:

David Blum - Nashville TN, US
Joslin Gemsch Cuenca - San Diego CA, US
Mark Dycaico - San Diego CA, US

Assignee:

BP Corporation North America - Houston TX
Verenium Corporation - San Diego CA

International Classification:

C12N 9/42
C12N 9/14
C12N 15/00
C12N 1/20
C12P 21/06
C12P 19/00
C12P 7/06
A62D 3/00
C07H 21/04
A61K 38/47
A23C 17/00
A01H 5/00

US Classification:

435209, 435195, 435 691, 435 911, 4353201, 4352523, 43525411, 4352625, 435 72, 435161, 536 231, 536 232, 530350, 5303871, 424 9461, 424 941, 4241301, 426 11, 426 16, 426 42, 800278, 800298

Abstract:

This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e. g. , endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides cellulase activity, e. g. , endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.

US Patent:

8043839, Oct 25, 2011

Filed:

Feb 14, 2007

Appl. No.:

12/279326

Inventors:

David Weiner - Del Mar CA, US
David Blum - Nashville TN, US
Alexander Varvak - San Diego CA, US
Shaun Healey - Carlsbad CA, US
Kristine Chang - San Diego CA, US
Geoff Hazlewood - Newbury, GB
Thomas Todaro - San Diego CA, US
Grace Desantis - San Diego CA, US
Hwai Chang - San Marcos CA, US
Connie Jo Hansen - San Diego CA, US
Scott W. Beaver - San Marcos CA, US
Thomas Woodward - Scottsville VA, US
Charles Hancock - San Marcos CA, US

Assignee:

Verenium Corporation - San Diego CA

International Classification:

C12N 9/24
C12N 1/20
C12N 1/15
C12N 1/16
C12N 1/19
C12N 15/70
C12P 21/06
C07H 21/04
A01H 5/00

US Classification:

435200, 435 691, 4353201, 4352523, 536 232, 800298, 800312, 800314, 800320, 8003201, 8003202, 8003203

Abstract:

The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e. g. , catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

US Patent:

20130289246, Oct 31, 2013

Filed:

Sep 30, 2011

Appl. No.:

13/877163

Inventors:

James E. Crowe - Nashville TN, US
Jens C. Krause - Freiburg, DE
David L. Blum - Athens GA, US

Assignee:

VANDERBILT UNIVERSITY - Nashville TN

International Classification:

C07K 16/10

US Classification:

530381, 53038825, 5303873

Abstract:

The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of influenza virus infections. In particular, these antibodies may neutralize or limit the replication of influenza virus. Also disclosed are improved methods for producing such monoclonal antibodies, including novel immunogens for use in vaccination and production of protective immune responses.

US Patent:

20130330783, Dec 12, 2013

Filed:

Apr 19, 2013

Appl. No.:

13/866790

Inventors:

David Blum - Brentwood TN, US
Joslin Gemsch Cuenca - San Diego CA, US
Mark Dycaico - San Diego CA, US

Assignee:

BP Corporation North America Inc. - Houston TX

International Classification:

C12P 7/10
C12N 9/42

US Classification:

435 99, 536 232, 4353201, 435325, 43525411, 4352542, 435348, 435419, 435209, 435165

Abstract:

This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.

US Patent:

20150139977, May 21, 2015

Filed:

Oct 22, 2014

Appl. No.:

14/521317

Inventors:

- Naperville IL, US
David Blum - Nashville TN, US
Alexander Varvak - San Diego CA, US
Shaun Healey - Carlsbad CA, US
Kristine Chang - San Diego CA, US
Geoff Hazlewood - Newbury, GB
Thomas Todaro - San Diego CA, US
Grace Desantis - San Diego CA, US
Hwai Chang - San Marcos CA, US
Connie Jo Hansen - San Diego CA, US
Scott W. Beaver - San Marcos CA, US
Thomas Woodward - Scottsville VA, US
Charles Hancock - San Marcos CA, US

International Classification:

C12N 9/24
C12P 19/02
C12P 19/14
D21H 17/00
A23K 1/16
D21C 9/10
D06L 3/14
D06L 3/11
A23L 1/09
A23K 1/00
C12N 9/42
D21C 3/00

US Classification:

424 9461, 435209, 435 99, 435165, 435155, 435198, 435196, 435205, 435192, 435189, 435201, 435197, 435193, 435162, 506 1, 162 5, 162174, 162 72, 8109, 426 61, 426 7, 426 2

Abstract:

The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.