David C Capps

US Patent:

46265406, Dec 2, 1986

Filed:

Oct 10, 1984

Appl. No.:

6/658100

Inventors:

David B. Capps - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3147
C07D21908

US Classification:

514297

Abstract:

Substituted 1-amino-4-nitroacridinones, their method of manufacture, pharmaceutical compositions and their use as antibacterial and antitumor agents are herein described.

US Patent:

42073200, Jun 10, 1980

Filed:

Aug 28, 1978

Appl. No.:

5/937234

Inventors:

David B. Capps - Ann Arbor MI
Mario M. Angelo - Ypsilanti MI
Townley P. Culbertson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31535

US Classification:

42424856

Abstract:

Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts having the formula I: ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, C. sub. 4 -C. sub. 6 cycloalkyl, di(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, 4-morpholinyl or 2,2-dimethylhydrazino; R. sub. 2 is hydrogen, lower alkyl, lower alkylamino, di(lower alkyl)amino, C. sub. 4 -C. sub. 6 cycloalkylamino, lower alkoxy(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, hexahydro-1H-azepin-1-yl, 4-morpholinyl, benzylamino, N-methylbenzylamino or 2-phenylethylamino; R. sub. 3 is hydrogen or methyl; X is an anion; with the proviso that at least one of R. sub. 1 and R. sub. 2 is other than hydrogen, lower alkyl or C. sub. 4 -C. sub. 6 cycloalkyl; and with the further proviso that when R. sub.

US Patent:

46043900, Aug 5, 1986

Filed:

May 24, 1985

Appl. No.:

6/738195

Inventors:

Edward F. Elslager - Ann Arbor MI
Leslie M. Werbel - Ann Arbor MI
Daniel F. Ortwine - Saline MI
Donald F. Worth - Ann Arbor MI
Howard D. H. Showalter - Ann Arbor MI
David B. Capps - Ann Arbor MI
Ellen M. Berman - Ann Arbor MI
Vlad E. Gregor - Ann Arbor MI
Anthony D. Sercel - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31415
A61K 3154
C07D49106
C07D51706

US Classification:

514222

Abstract:

Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.

US Patent:

45887306, May 13, 1986

Filed:

Aug 22, 1985

Appl. No.:

6/768310

Inventors:

David B. Capps - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3144
C07D40104
C07D21906
C07D21908

US Classification:

514287

Abstract:

Pyrazolo[3,4,5-k1]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.

US Patent:

45555729, Nov 26, 1985

Filed:

Jun 15, 1984

Appl. No.:

6/619258

Inventors:

David B. Capps - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D47102
A61K 3141

US Classification:

546 14

Abstract:

Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.

US Patent:

46210865, Nov 4, 1986

Filed:

Jan 22, 1986

Appl. No.:

6/821318

Inventors:

David B. Capps - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3141
C07D47102

US Classification:

514287

Abstract:

Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.