David U Chau

US Patent:

20130289019, Oct 31, 2013

Filed:

Apr 25, 2013

Appl. No.:

13/870739

Inventors:

David T. Chau - Ashburn VA, US

Assignee:

Amazing Grace, Inc. - Ashburn VA

International Classification:

A61K 31/5513
A61K 31/4995
A61K 31/14
A61K 31/46
A61K 31/455

US Classification:

514215, 514220, 514319, 51425216, 514291, 514356, 514643, 514424, 514479, 514278, 514250, 514343

Abstract:

One embodiment of an aspect of the present invention is a method for lessening the symptoms of depression, anxiety, and post-traumatic stress disorder comprising the step of administering a therapeutically effective quantity of a cholinergic M1 receptor antagonist and a therapeutically effective quantity of one or more cholinomimetic agents to lessen the symptoms of depression, anxiety, and post-traumatic stress disorder. Typically, the cholinergic M1 receptor antagonist is selected from the group consisting of telenzepine, amytriptyline, biperiden, trihexyphenidyl, darifenacin, dicyclomine, and tiotropium. Another aspect of the present invention is directed to methods and compositions employing other therapeutic agents and combinations of therapeutic agents for emulating the theoretical pharmacological effects of the non-selective mAChR antagonist scopolamine. The invention also encompasses pharmaceutical compositions incorporating one or more therapeutic agents and a pharmaceutically acceptable carrier.