David J Dean

US Patent:

8334272, Dec 18, 2012

Filed:

Oct 12, 2010

Appl. No.:

12/902240

Inventors:

David A. Dean - Rochester NY, US
Robert Christopher Geiger - Fort Myers FL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

A61K 31/70
C07H 21/02
C07H 21/04
C12P 19/34
C12Q 1/68

US Classification:

514 44, 536 245, 435 61, 435 911, 435325, 435375

Abstract:

The present invention provides methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in increasing gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications.

US Patent:

20090069266, Mar 12, 2009

Filed:

Jun 27, 2008

Appl. No.:

12/163152

Inventors:

David A. Dean - Rochester NY, US
Robert Christopher Geiger - Fort Myers FL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

A61K 31/7088
C12N 15/09

US Classification:

514 44, 435455

Abstract:

The present invention provides compositions and methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in increasing gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications.

US Patent:

20130197064, Aug 1, 2013

Filed:

Mar 14, 2011

Appl. No.:

13/634422

Inventors:

David A. Dean - Rochester NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

C12N 15/113
C12N 15/85
A61K 48/00

US Classification:

514 44 R, 536 241, 4353201, 43525233, 435325, 435455, 604 22, 604501

Abstract:

One aspect of the invention relates to an isolated nuclear targeting molecule that includes a fragment of a mammalian glycoprotein 36 (gp36, also known as T1-α or podoplanin) gene expressed in type I alveolar epithelial cells. Plasmids containing the isolated nuclear targeting molecule which are useful for affording nuclear uptake of the plasmid DNA in type I alveolar epithelial cells but not type II alveolar epithelial cells, and compositions and host cells containing such plasmids are also disclosed. Use of the plasmids for targeting an exogenous DNA into nuclei of type I alveolar epithelial cells is described herein.

US Patent:

44465831, May 8, 1984

Filed:

Jun 28, 1982

Appl. No.:

6/392746

Inventors:

David F. Dean - Rochester NY

International Classification:

E03C 124

US Classification:

4206

Abstract:

A pair of rigid discs are riveted coaxially together at their centers to permit relative rotation therebetween. One disc has therethrough a pair of spaced, elongate slots, and the other a plurality of pairs of circular openings which are arranged about the axis of the discs in such a manner that only one pair thereof at a time can register with the two slots in said one disc. A resilient backing layer of rubber or the like is secured to the outer face of one of the discs and has therethrough a plurality of slots or openings which are similar to, and in registry with, the slots or openings in the disc to which it is secured. In use the overflow strainer of a tub is removed to expose the overflow opening, and the discs are rotatably adjusted until one of the pairs of circular openings registers through the pair of slots with the strainer mounting lugs. The same screws which were used to secure the overflow strainer to the tub are then used to secure the seal to the tub with the resilient backing material closing off the overflow opening. Each pair of circular openings is adapted to a register with a different type of strainer mount, so that the seal can be used on different types of tubs.