David C Doucette

US Patent:

41432037, Mar 6, 1979

Filed:

Mar 19, 1976

Appl. No.:

5/668425

Inventors:

Peter N. Rigopulos - Boxford MA
Charles W. Desaulniers - Franklin MA
David E. Doucette - Wakefield MA

Assignee:

Amicon Corporation - Lexington MA

International Classification:

B32B 516
B32B 904

US Classification:

428407

Abstract:

Particles having a mean diameter from 0. 1 to 50 micrometers and having a solid core of water-impermeable polyacrylonitrile and a partially hydrolyzed hydrophilic surface layer enclosing the core containing from 0. 001 to 0. 8 milliequivalents of carboxyl or carboxylate groups per dry gram, the surface layer amounting to 0. 01 to 20% by weight of the particles, are useful as a solid phase insoluble support to which biospecific reagents such as antigens or antibodies can be coupled. Variants include supports in which N-hydroxysuccinimide or various spacer arms are coupled to the carboxyl or carboxylate groups.