David J Duarte

US Patent:

20200164374, May 28, 2020

Filed:

Jan 30, 2020

Appl. No.:

16/777795

Inventors:

- Oakland CA, US
Justin Stovner - Long Beach CA, US
Hugo Salas - Bell CA, US
David Duarte - Norwalk CA, US
Jered Haun - Irvine CA, US
Alan Widgerow - Irvine CA, US
Derek Banyard - Orange CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

B01L 3/00
B01L 9/00
G01N 35/04
B04B 5/04
B04B 9/10

Abstract:

Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180 on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).

US Patent:

20180361382, Dec 20, 2018

Filed:

Aug 10, 2018

Appl. No.:

16/101254

Inventors:

- Oakland CA, US
Justin Stovner - Long Beach CA, US
Hugo Salas - Bell CA, US
David Duarte - Norwalk CA, US
Jered Haun - Irvine CA, US
Alan Widgerow - Irvine CA, US
Derek Banyard - Orange CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

B01L 3/00
B01L 9/00

Abstract:

Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180 on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).