David B Frennesson from 164 Conrad St, Union City, CT 06770, age 60, Phone: (203)7296224

Topoisomerase Inhibitors
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US Patent:

6677450, Jan 13, 2004
Filed:

Sep 27, 2001
Appl. No.:

09/965976
Inventors:

Mark G. Saulnier - Higganum CT
Edward H. Ruediger - Greenfield Park, CA
Neelakantan Balasubramanian - Madison CT
Mikael Mahler - Outremont, CA
Francis Beaulieu - Laprairie, CA
Carol Bachand - Candiac, CA
David B. Frennesson - Naugatuck CT
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07H 906
US Classification:

540545
Abstract:

The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.

Anhydro Sugar Derivatives Of Indolocarbazoles
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US Patent:

6686385, Feb 3, 2004
Filed:

May 7, 2003
Appl. No.:

10/431221
Inventors:

Mark G. Saulnier - Higganum CT
Edward H. Ruediger - Greenfield Park, CA
Neelakantan Balasubramanian - Madison CT
David Bertil Frennesson - Naugatuck CT
Mikael Mahler - Outremont, CA
Kurt Zimmermann - Durham CT
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

A61K 3155
US Classification:

514410, 548416
Abstract:

The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.

Topoisomerase I Selective Cytotoxic Sugar Derivatives Of Indolopyrrolocarbazoles
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US Patent:

6855698, Feb 15, 2005
Filed:

Mar 22, 2002
Appl. No.:

10/103908
Inventors:

Edward H. Ruediger - Greenfield Park, CA
Mark G. Saulnier - Higganum CT, US
Francis Beaulieu - Laprairie, CA
Carol Bachand - Candiac, CA
Byron Hepler Long - Doylestown PA, US
David B. Frennesson - Naugatuck CT, US
Kurt Zimmermann - Durham CT, US
B. Narasimhulu Naidu - Durham CT, US
Karen Stoffan - Hartford CT, US
Denis Robert St. Laurent - Newington CT, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

A01N043/04
A61K031/70
US Classification:

514 43, 514 42, 514410, 536 187, 536 221, 536 271, 536 286
Abstract:

The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.

Pyrrolotriazine Kinase Inhibitors
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US Patent:

7534792, May 19, 2009
Filed:

Jul 5, 2007
Appl. No.:

11/773466
Inventors:

Mark D. Wittman - Wallingford CT, US
Harold Mastalerz - Guilford CT, US
Kurt Zimmermann - Durham CT, US
Mark G. Saulnier - Newington CT, US
Upender Velaparthi - Cheshire CT, US
Dolatrai M. Vyas - Madison CT, US
Guifen Zhang - Wallingford CT, US
Walter Lewis Johnson - Waterbury CT, US
David B. Frennesson - Naugatuck CT, US
Xiaopeng Sang - Glastonbury CT, US
Peiying Liu - Madison CT, US
David R. Langley - Meriden CT, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D 487/04
C07D 403/12
C07D 403/14
A61K 31/53
A61P 19/02
A61P 35/00
US Classification:

514243, 544183
Abstract:

The invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Pyrrolotriazine Kinase Inhibitors
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US Patent:

7879855, Feb 1, 2011
Filed:

Mar 26, 2009
Appl. No.:

12/411724
Inventors:

Mark D. Wittman - Wallingford CT, US
Harold Mastalerz - Guilford CT, US
Kurt Zimmermann - Durham CT, US
Mark G. Saulnier - Newington CT, US
Upender Velaparthi - Cheshire CT, US
Dolatrai M. Vyas - Madison CT, US
Guifen Zhang - Wallingford CT, US
Walter Lewis Johnson - Waterbury CT, US
David B. Frennesson - Naugatuck CT, US
Xiaopeng Sang - Glastonbury CT, US
Peiying Liu - Madison CT, US
David R. Langley - Meriden CT, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

A61K 31/53
A61P 35/00
C07D 487/04
C07D 401/14
A61P 19/02
US Classification:

514243, 544183
Abstract:

The invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Pyrrolotriazine Kinase Inhibitors
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US Patent:

8445676, May 21, 2013
Filed:

Oct 8, 2009
Appl. No.:

13/123305
Inventors:

Ashok Vinayak Purandare - Pennington NJ, US
David B. Frennesson - Naugatuck CT, US
Muthoni G. Kamau - Lawrenceville NJ, US
Lalgudi S. Harikrishnan - Skillman NJ, US
Mark G. Saulnier - Higganum CT, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D 487/04
A61K 31/53
A61P 35/00
US Classification:

544183, 514243
Abstract:

The present invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity of such as Jak2 and CK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

Pyrrolotriazine Kinase Inhibitors
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US Patent:

8592579, Nov 26, 2013
Filed:

Aug 7, 2012
Appl. No.:

13/568750
Inventors:

Mark D. Wittman - Wallingford CT, US
Harold Mastalerz - Guilford CT, US
Kurt Zimmermann - Durham CT, US
Mark G. Saulnier - Higganum CT, US
Upender Velaparthi - Cheshire CT, US
Dolatrai M. Vyas - Madison CT, US
Guifen Zhang - Wallingford CT, US
Walter Lewis Johnson - Waterbury CT, US
David B. Frennesson - Naugatuck CT, US
Xiaopeng Sang - Glastonbury CT, US
Peiying Liu - Madison CT, US
David R. Langley - Meriden CT, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D 487/04
C07D 401/14
A61K 31/53
A61P 35/00
US Classification:

544183, 514243
Abstract:

The invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Anhydro Sugar Derivatives Of Indolocarbazoles
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US Patent:

20020111375, Aug 15, 2002
Filed:

Sep 27, 2001
Appl. No.:

09/965069
Inventors:

Mark Saulnier - Higganum CT, US
Edward Ruediger - Greenfield Park, CA
Neelakantan Balasubramanian - Madison CT, US
David Frennesson - Naugatuck CT, US
Mikael Mahler - Outremont, CA
Kurt Zimmermann - Durham CT, US
International Classification:

C07D487/14
A61K031/407
US Classification:

514/410000, 548/416000, 548/417000
Abstract:

The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.

David B Frennesson