David J Goldstein

US Patent:

8535887, Sep 17, 2013

Filed:

May 21, 2010

Appl. No.:

12/785060

Inventors:

Arthur Bertelsen - Ridgewood NJ, US
Jacques Fellay - Durham NC, US
Dongliang Ge - Raleigh NC, US
David B. Goldstein - Durham NC, US
John G. McHutchison - Chapel Hill NC, US
Ping Qiu - Edison NJ, US
Kevin Shianna - Durham NC, US
Jason S. Simon - Westfield NJ, US
Alexander J. Thompson - Durham NJ, US
Thomas Urban - Durham NC, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435 611, 435 5, 435 61, 435 612

Abstract:

The present invention provides genetic markers on human chromosome 19 that are associated with a beneficial response to interferon alpha (IFN-α). These IFN-α response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment with IFN-α pharmaceutical compositions and drug products, in methods of treating patients having a disease susceptible to treatment with an IFN-α, and in methods for selecting the most appropriate therapy for such patients.

US Patent:

55141390, May 7, 1996

Filed:

Sep 2, 1994

Appl. No.:

8/300379

Inventors:

David B. Goldstein - Hoboken NJ
Timothy Haines - Hoboken NJ

Assignee:

Hudson Surgical Design, Inc. - Stewartsville NJ

International Classification:

A61B 1756

US Classification:

606 79

Abstract:

A distal femur resecting apparatus for use in the preparation of a human distal femur for the implantation of a human femoral prosthesis. The resecting apparatus includes a positioning apparatus and a pattern device. The positioning apparatus includes a positioning block for attachment to a femur, an adjustment block having an intermedullary rod extending into the femur, and a rotational alignment device for attachment of the pattern device to the positioning apparatus. The pattern device comprises an individual or pair of mediolaterally located plates having a cutting path described therethrough similar in shape to the interior profile of a human femoral prosthesis. The cutting path guides a reciprocating, oscillating, or rotating cutting tool along a path for removing material from some or all of the distal femur to shape the distal femur to accept a distal femoral prosthesis.

US Patent:

55973795, Jan 28, 1997

Filed:

Nov 18, 1994

Appl. No.:

8/342143

Inventors:

Timothy G. Haines - Hoboken NJ
David B. Goldstein - Hoboken NJ

Assignee:

Hudson Surgical Design, Inc. - Rutherford NJ

International Classification:

A61B 1756

US Classification:

606 80

Abstract:

The apparatus of the present invention includes a number of components including a guide body component, an extension block component, a rotating arm component, an extension rod component, and a tibial referencing component. The guide body component contacts the distal-most surface of the femur. Its location is based off of the posterior femoral condyles and the surface of the distal-most femoral resection or the unresected distal-most femoral surface. The rotating arm component is interconnected with the guide body and may rotate with respect thereto, thus allowing for the direct or indirect adjustment of the rotating alignment of cutting guides for resecting the distal femur. The rotating arm component carries arms with drill screw apertures which direct placement of drill holes in the femur which are used to attach a cutting guide to the femur. The rotating arm component is attached to the extension rod component which extends to the tibial referencing component which references the location and orientation of the proximal resected surface of the tibia. Thus the rotating alignment of the distal femoral prosthesis is established with respect to the orientation of the resected proximal tibial surface.

US Patent:

57558035, May 26, 1998

Filed:

May 17, 1996

Appl. No.:

8/649465

Inventors:

Timothy G. Haines - Rutherford NJ
David B. Goldstein - Weehawken NJ

Assignee:

Hudson Surgical Design - Weehauken NJ

International Classification:

A61F 238

US Classification:

623 20

Abstract:

An implant is provided for which has an outer bearing surface and an inner attachment surface. The outer bearing surface functions as a joint contact surface for a reconstructed bone joint. The inner attachment surface contacts a bone and is attached thereto. The inner attachment surface of the implant is curvilinear from the anterior to the posterior area of the femur, and is also curvilinear from the medial to the lateral areas of the femur to approximates the shape of natural femur. The resection of the femur for accommodating the implant can be properly performed by a milling device employing one or more curvilinear milling bits.