David C Grainger

US Patent:

7501157, Mar 10, 2009

Filed:

Jan 13, 2005

Appl. No.:

11/035849

Inventors:

Guoqiang Mao - Smyrna GA, US
Steven W. Metzger - Westminster CO, US
Michael J. Lochhead - Boulder CO, US
David A. Goldberg - Boulder CO, US
Charles H. Greef - Louisville CO, US
David W. Grainger - Fort Collins CO, US

Assignee:

Accelr8 Technology Corporation - Denver CO

International Classification:

B05D 3/02

US Classification:

427384, 4273855, 4273881, 4273897, 4273935

Abstract:

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.