David P Head

US Patent:

6469779, Oct 22, 2002

Filed:

Feb 4, 1998

Appl. No.:

09/018452

Inventors:

Thomas M. Baer - Mountain View CA
Mark A. Enright - Cupertino CA
David F. Head - Los Gatos CA
Christopher E. Todd - San Jose CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

G01N 100

US Classification:

356 36, 359385

Abstract:

Systems and methods for laser capture microdissection are disclosed. A method of laser capture microdissection includes providing a sample that is to undergo laser capture microdissection; positioning said sample within an optical axis of a laser capture microdissection instrument; providing a transfer film carrier having a substrate surface and a laser capture microdissection transfer film coupled to said substrate surface; placing said laser capture microdissection transfer film in juxtaposition with said sample with a pressure sufficient to allow laser capture microdissection transfer of a portion of said sample to said laser capture microdissection transfer film, without forcing nonspecific transfer of a remainder of said sample to said laser capture microdisection film; and then transferring a portion of said sample to said laser capture microdissection transfer film, without forcing nonspecific transfer of a remainder of said sample to said laser capture microdissection transfer film. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

US Patent:

6495195, Dec 17, 2002

Filed:

Feb 14, 1997

Appl. No.:

08/800882

Inventors:

Thomas M. Baer - Mountain View CA
David F. Head - Los Gatos CA
John S. Toeppen - Livermore CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

A61L 3108

US Classification:

427 211, 427 231, 427555, 427556, 427596

Abstract:

A thermoplastic film for LCM tissue transfer is thermally coupled to a broadband energy-absorbing material. The broadband energy-absorbing material may either be introduced into the film composition as a dopant or may be in thermal contact with the film.

US Patent:

6512576, Jan 28, 2003

Filed:

Jul 17, 2000

Appl. No.:

09/617742

Inventors:

Thomas M. Baer - Mountain View CA
Mark A. Enright - Cupertino CA
David F. Head - Los Gatos CA
Christopher E. Todd - San Jose CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

G01N 100

US Classification:

356 36, 359385

Abstract:

Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes an illumination/laser beam delivery system that is adapted to both illuminate a sample and provide energy for laser capture microdissection of the sample. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

US Patent:

6528248, Mar 4, 2003

Filed:

May 1, 2000

Appl. No.:

09/562495

Inventors:

Ann Bennett Lossing - Capitola CA
Sherrie L. Ransom - San Francisco CA
Steven T. Kunitake - San Carlos CA
Robert H. Reamey - Palo Alto CA
David F. Head - Los Gatos CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

A01G 506

US Classification:

435 4, 427 4

Abstract:

Systems and methods are described for barriers on laser capture microdissection samples. A method of processing a biological sample for laser capture microdissection, includes: providing the biological sample; and applying a substance to the biological sample so as to provide a barrier between the biological sample and a surrounding environment. The systems and methods provide advantages because non-specific pick-up is reduced, visualization is improved, sample degradation is reduced, and contamination is reduced.

US Patent:

6639657, Oct 28, 2003

Filed:

Jul 23, 1998

Appl. No.:

09/121677

Inventors:

Thomas M. Baer - Mountain View CA
Mark A. Enright - Cupertino CA
David F. Head - Los Gatos CA
Christopher E. Todd - San Jose CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

G01N 100

US Classification:

356 36

Abstract:

Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a translation stage joystick subsystem. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

US Patent:

6697149, Feb 24, 2004

Filed:

Jul 23, 1998

Appl. No.:

09/121691

Inventors:

Thomas M. Baer - Mountain View CA
Mark A. Enright - Cupertino CA
David F. Head - Los Gatos CA
Christopher E. Todd - San Jose CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

G01N 100

US Classification:

356 36

Abstract:

Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a vacuum chuck subsystem that is adapted to hold a microscope slide down during the process of laser capture microdissection. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

US Patent:

6700653, Mar 2, 2004

Filed:

Oct 17, 2002

Appl. No.:

10/272879

Inventors:

Thomas M. Baer - Mountain View CA
Mark A. Enright - Cupertino CA
David F. Head - Los Gatos CA
Christopher E. Todd - San Jose CA

Assignee:

Arcturus Engineering, Inc. - Mountain View CA

International Classification:

G01N 100

US Classification:

356 36

Abstract:

Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes an illumination/laser beam delivery system that is adapted to both illuminate a sample and provide energy for laser capture microdissection of the sample. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

US Patent:

6887703, May 3, 2005

Filed:

Feb 16, 2001

Appl. No.:

09/788117

Inventors:

Thomas M. Baer - Mountain View CA, US
Robert H. Reamey - Palo Alto CA, US
David F. Head - Saratoga CA, US
Ali Firouzi - Redwood City CA, US
David Ching - Mountain View CA, US

Assignee:

Arturus Bioscience, Inc. - Mountain View CA

International Classification:

C12N005/00

US Classification:

435325, 356 36, 427 211, 428 401

Abstract:

The present invention generally provides an improved transfer film having multiple layers for laser micro-capture of a sample. The transfer film for laser micro-capture includes distinct layers for expansion and adhesion in order to optimize the performance of the transfer film. A transfer film including a spring-back layer is also disclosed.