David A Hecht

US Patent:

46743804, Jun 23, 1987

Filed:

Jan 29, 1986

Appl. No.:

6/823949

Inventors:

David Hecht - New York NY
Steven F. Schultz - East Hampton NY

International Classification:

B26D 726
B26D 103

US Classification:

834252

Abstract:

An apparatus for longitudinally cutting a web into a plurality of ribbons has a plurality of blade holders mounted so that the relative spacing as well as the overall lateral position of the blades can be shifted in response to growth, shrinkage, and lateral shifting of webs, while maintaining the blades perpendicular to the direction of travel of the web. The blades are held in holders having the ends interconnected by a parallelogram linkage and clamped to a rigid bar and a flexible extensible rod.

US Patent:

47141824, Dec 22, 1987

Filed:

Jan 28, 1987

Appl. No.:

7/007771

Inventors:

David Hecht - New York NY

International Classification:

A41H 4300
D04D 710

US Classification:

223 46

Abstract:

A method and apparatus for making bows comprises a tie member wrapping machine which wraps a tie member around a run of ribbon and twists it at the free ends. In order to dispose the tie at the center of the run of ribbon, a jig is mounted on the head of the wrapping machine to position the ribbon at the slot of the machine and to center the ribbon relative to the slot. The jig includes diverging rods around which the ribbon is wrapped. As the ribbon is moved rearwardly into the slot, a slack develops in the ribbon to permit a tight cinching of the central portion by the tie member.

US Patent:

20220298172, Sep 22, 2022

Filed:

May 30, 2022

Appl. No.:

17/804566

Inventors:

- San Diego CA, US
Paul E. Erdman - San Diego CA, US
Aparajita Hoskote Chourasia - San Diego CA, US
Leah M. Fung - San Diego CA, US
David Aaron Hecht - Chula Vista CA, US
Imelda Lam - San Diego CA, US
Frank Mercurio - Rancho Santa Fe CA, US
Robert W. Sullivan - Vista CA, US
Eduardo Torres - San Diego CA, US

Assignee:

BioTheryX, Inc. - San Diego CA

International Classification:

C07D 495/04
C07D 401/04
C07D 401/14

Abstract:

The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

US Patent:

20230071529, Mar 9, 2023

Filed:

Dec 14, 2020

Appl. No.:

17/757105

Inventors:

- San Diego CA, US
Paul E. Erdman - San Diego CA, US
Leah M. Fung - San Diego CA, US
David Aaron Hecht - Chula Vista CA, US
Frank Mercurio - Rancho Santa Fe CA, US
Robert W. Sullivan - Vista CA, US

Assignee:

BioTheryX, Inc. - San Diego CA

International Classification:

C07D 495/04
C07D 401/14
C07D 417/14
C07F 5/02
C07D 405/14

Abstract:

Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.

US Patent:

20230002371, Jan 5, 2023

Filed:

Sep 14, 2020

Appl. No.:

17/753686

Inventors:

- San Diego CA, US
Aparajita Hoskote Chourasia - San Diego CA, US
Paul E. Erdman - San Diego CA, US
Leah M. Fung - San Diego CA, US
David Aaron Hecht - Chula Vista CA, US
Imelda Lam - San Diego CA, US
Frank Mercurio - Rancho Santa Fe CA, US
Robert W. Sullivan - Vista CA, US
Eduardo Torres - San Diego CA, US

International Classification:

C07D 471/04
C07D 401/14
C07D 495/04
C07D 417/14
C07D 471/14
C07D 405/14
A61P 35/00
A61P 11/00

Abstract:

Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.

US Patent:

20200369679, Nov 26, 2020

Filed:

May 26, 2020

Appl. No.:

16/882750

Inventors:

- San Diego CA, US
Paul E. Erdman - San Diego CA, US
Aparajita Hoskote Chourasia - San Diego CA, US
Leah Fung - San Diego CA, US
David Aaron Hecht - Chula Vista CA, US
Imelda Lam - San Diego CA, US
Frank Mercurio - Rancho Santa Fe CA, US
Robert Sullivan - Vista CA, US
Eduardo Torres - San Diego CA, US

International Classification:

C07D 495/04
C07D 401/04
C07D 401/14

Abstract:

The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

US Patent:

20200264771, Aug 20, 2020

Filed:

May 7, 2020

Appl. No.:

16/868932

Inventors:

- Milpitas CA, US
Kenneth Andrew Feehan - Belmont CA, US
Paul Leonard Futter - Cary NC, US
David Samuel Hecht - San Diego CA, US
Joel Christopher Kent - Fremont CA, US
Robert William Kitchin - Los Gatos CA, US
Kenneth John North - San Carlos CA, US
James Roney - Fremont CA, US
Jung Verheiden - San Francisco CA, US
Forrest Kim Wunderlich - El Granada CA, US

Assignee:

ELO TOUCH SOLUTIONS, INC. - Milpitas CA

International Classification:

G06F 3/0488
G06F 3/041
G06F 1/16
G06F 3/044

Abstract:

Techniques for providing multi-user multi-touch projected capacitive touch sensors are disclosed herein. Some embodiments may include a method that includes receiving a first sense signal from a first sensing array, the first sensing array configured to provide the first sense signal indicating a first touch on a first touch surface of a touch substrate as well as receiving a second sense signal from a second sensing array, the second sensing array configured to provide the second sense signal indicating a second touch on a second touch surface of a second touch substrate occurring concurrently to the first touch. The method may further include determining whether the first touch and the second touch share at least one anti-ghost. The method may also include associating the first touch and the second touch with a common touch entity in response to determining that the first touch and the second touch share the at least one anti-ghost.

US Patent:

20200048277, Feb 13, 2020

Filed:

Jul 25, 2019

Appl. No.:

16/522481

Inventors:

- Chappaqua NY, US
Aparajita Hoskote Chourasia - San Diego CA, US
Paul E. Erdman - San Diego CA, US
Leah Fung - San Diego CA, US
David Aaron Hecht - Chula Vista CA, US
Frank Mercurio - Rancho Santa Fe CA, US
Robert Sullivan - Vista CA, US
Joseph P. Vacca - Telford PA, US

International Classification:

C07D 495/04
A61P 35/00
C07D 417/14
C07D 401/14
C07D 403/14

Abstract:

The present application provides compounds that modulate CDK protein function. Methods of making the compounds, compositions containing the compounds, and uses of the compounds for treating or ameliorating of diseases, disorders, or conditions associated with CDK proteins, are also disclosed.