David W Holley

US Patent:

7849850, Dec 14, 2010

Filed:

Feb 28, 2003

Appl. No.:

10/375957

Inventors:

William G. Atterbury - Columbus OH, US
Chad E. Bouton - Delaware OH, US
David R. Busick - Lewis Center OH, US
James E. Dvorsky - Norwich Township OH, US
Peter A. Gaydos - Hilliard OH, US
David A. Holley - Lancaster OH, US
Daniel D. Meek - Canal Winchester OH, US
Gregory A. Trees - Columbus OH, US

Assignee:

Battelle Memorial Institute - Columbus OH

International Classification:

A61M 11/00
B05B 5/00
F23D 11/32

US Classification:

12820014, 239692

Abstract:

An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.

US Patent:

20130020727, Jan 24, 2013

Filed:

Jul 16, 2012

Appl. No.:

13/550026

Inventors:

Thomas A. KLAUSING - Powell OH, US
Jeffrey T. STROUP - Upper Arlington OH, US
Brian C. KELLEY - Pataskala OH, US
Joseph E. ZAMBANINI - Delaware OH, US
David A. HOLLEY - Lancaster OH, US

Assignee:

CARDINAL HEALTH 414, LLC. - Dublin OH

International Classification:

B01J 19/00
C07B 47/00

US Classification:

260 1, 422159

Abstract:

Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.

US Patent:

60763280, Jun 20, 2000

Filed:

Aug 8, 1997

Appl. No.:

8/907586

Inventors:

Scott N. Danhof - Plain City OH
Christopher G. Ross - Columbus OH
Phillip A. Green - Columbus OH
Colin A. Chong - Columbus OH
David A. Holley - Lancaster OH
Jeffrey L. Hall - Sorento IL
Michael A. Spicer - Trenton IL

Assignee:

Arrow Group Industries, Inc. - Wayne NJ

International Classification:

G04B 141

US Classification:

52762

Abstract:

Connection apparatus for connecting frame members and panel members is provided for constructing a storage building primarily from sheet metal. The apparatus utilizes connecting members that may be made from thermoplastic or metal materials. The number of threaded fasteners and time required to assemble the storage building is reduced dramatically from that of prior designs.

US Patent:

20230049247, Feb 16, 2023

Filed:

Jul 23, 2022

Appl. No.:

17/871907

Inventors:

- Columbus OH, US
Kavitha Dasu - Powell OH, US
Russel R. Sirabian - Columbus OH, US
Amy Dindal - Rockland MA, US
Jeffrey Ellis - Columbus OH, US
Amy Heintz - Dublin OH, US
Dan Garbark - Columbus OH, US
Nathan Bryant - Columbus OH, US
John Tallarico - Columbus OH, US
Joseph Casciano - Columbus OH, US
Slawomir Winecki - Columbus OH, US
David Holley - Columbus OH, US
Joshua James - Columbus OH, US
Keith Brown - Solon OH, US
Doug Hendry - Columbus OH, US
Darwin Argumedo - Columbus OH, US
Aaron Frank - Dublin OH, US
Christopher Gordon Scheitlin - Columbus OH, US
Michael M. Miller - Worthington OH, US

International Classification:

C02F 1/44
C02F 1/04
C02F 1/72

Abstract:

Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

US Patent:

20210361880, Nov 25, 2021

Filed:

Dec 12, 2019

Appl. No.:

17/311117

Inventors:

- Indianapolis IN, US
Corrie Jo BENNISON - Lewis Center OH, US
Jeffrey Richard HELD - Columbus OH, US
David Arthur HOLLEY - Lancaster OH, US
Noah John Scott LEMIRE - Columbus OH, US
Beverly Anne PIATT - Columbus OH, US
John Paul TALLARICO - Powell OH, US

International Classification:

A61M 5/315
A61M 5/20
A61M 5/32
A61M 5/19

Abstract:

A therapeutic agent delivery system () includes a housing () and a drive wheel () rotatably carried by the housing. A plunger rod () may be rotatable with the drive wheel relative to the housing from a first rotational configuration to a second rotational configuration. The plunger rod may be translatable relative to the housing from a first translational configuration to a second translational configuration. A plunger restraint () may maintain the plunger rod in the first translational configuration when the plunger rod is disposed in the first rotational configuration. The plunger restraint may permit the plunger rod to translate to the second translational configuration when the plunger rod is disposed in the second rotational configuration. A needle may move from a stowed configuration to a deployed configuration by the plunger rod when the plunger rod moves from the first translational configuration to the second translational configuration.

US Patent:

20200407241, Dec 31, 2020

Filed:

Jun 29, 2020

Appl. No.:

16/916085

Inventors:

- Columbus OH, US
Kavitha Dasu - Powell OH, US
Russel R. Sirabian - Columbus OH, US
Amy Dindal - Rockland MA, US
Jeffrey Ellis - Columbus OH, US
Amy Heintz - Dublin OH, US
Dan Garbark - Columbus OH, US
Nathan Bryant - Columbus OH, US
John Tallarico - Columbus OH, US
Joseph Casciano - Columbus OH, US
Slawomir Winecki - Columbus OH, US
David Holley - Columbus OH, US
Joshua James - Columbus OH, US
Keith Brown - Solon OH, US
Doug Hendry - Columbus OH, US
Darwin Argumedo - Columbus OH, US
Aaron Frank - Dublin OH, US

International Classification:

C02F 1/44
C02F 1/04
C02F 1/72

Abstract:

Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

US Patent:

20200353170, Nov 12, 2020

Filed:

Apr 9, 2020

Appl. No.:

16/845065

Inventors:

- Columbus OH, US
Timothy M. Blum - Columbus OH, US
David A. Holley - Columbus OH, US
John P. Tallarico - Columbus OH, US
Steven M. Madland - Columbus OH, US

International Classification:

A61M 5/20
A61M 5/315
A61M 5/32

Abstract:

An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.

US Patent:

20200030537, Jan 30, 2020

Filed:

Feb 9, 2018

Appl. No.:

16/484676

Inventors:

- Indianapolis IN, US
Corrie Jo BENNISON - Lewis Center OH, US
Robert Jonathan CAIN - Lewis Center OH, US
Michael Funk CHIAPPETTA - Greenwood IN, US
Jeffrey LeClair ELLIS - Columbus OH, US
David Arthur HOLLEY - Lancaster OH, US
Mark LAFEVER - Indianapolis IN, US
Beverly Ann PIATT - Columbus OH, US
John Paul TALLARICO - Powell OH, US

International Classification:

A61M 5/20

Abstract:

Processes and devices are disclosed for parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. The device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.