David F Horan

US Patent:

6902932, Jun 7, 2005

Filed:

Nov 16, 2001

Appl. No.:

10/008924

Inventors:

Gregory H. Altman - Dedham MA, US
David L. Kaplan - Concord MA, US
Rebecca L. Horan - Westfield MA, US
David J. Horan - Westfield MA, US

Assignee:

Tissue Regeneration, Inc. - Medford MA
Trustees of Tufts College - Medford MA

International Classification:

C12N005/06
C12N005/08
C12N011/08
C12N011/04
A61F002/00

US Classification:

435395, 424423, 424 937, 435177, 435180, 435182

Abstract:

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

US Patent:

8172901, May 8, 2012

Filed:

Mar 20, 2008

Appl. No.:

12/052719

Inventors:

Gregory H. Altman - Arlington MA, US
Enrico Mortarino - Hickory NC, US
David J. Horan - Westfield MA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

A61F 2/08

US Classification:

623 1312, 623 1311

Abstract:

A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from in-growth.

US Patent:

8623398, Jan 7, 2014

Filed:

Jul 30, 2012

Appl. No.:

13/561808

Inventors:

Gregory H. Altman - Arlington MA, US
Rebecca Horan - Arlington MA, US
David J. Horan - Westfield MA, US
Jingsong Chen - Virginia Beach VA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

A61F 2/00
C12N 11/02
C12N 5/07

US Classification:

424426, 435177, 435399

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e. g. , twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

US Patent:

8628791, Jan 14, 2014

Filed:

Mar 24, 2011

Appl. No.:

13/071396

Inventors:

Gregory H. Altman - Arlington MA, US
Jingson Chen - Virginia Beach VA, US
Rebecca L. Horan - Arlington MA, US
David J. Horan - Westfield MA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

A61F 2/00
C12N 11/02
C12N 5/00
C12N 5/07

US Classification:

424423, 435177, 435 398, 435399

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e. g. , twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

US Patent:

20040224406, Nov 11, 2004

Filed:

Mar 11, 2004

Appl. No.:

10/800134

Inventors:

Gregory Altman - Dedham MA, US
Jingsong Chen - Malden MA, US
Rebecca Horan - Westfield MA, US
David Horan - Westfield MA, US

Assignee:

Tissue Regeneration, Inc. - Medford MA

International Classification:

C12N005/02
B32B027/04

US Classification:

435/395000, 442/128000

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

US Patent:

20050089552, Apr 28, 2005

Filed:

Nov 16, 2004

Appl. No.:

10/990199

Inventors:

Gregory Altman - Dedham MA, US
David Kaplan - Concord MA, US
Rebecca Horan - Westfield MA, US
David Horan - Westfield MA, US

Assignee:

Tissue Regeneration, Inc. - Medford MA
Trustees of Tufts College - Medford MA

International Classification:

A61F002/08
A61K038/17
C07K014/435

US Classification:

424445000, 623013170, 623013190, 435395000, 530353000

Abstract:

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

US Patent:

20100209405, Aug 19, 2010

Filed:

Apr 29, 2010

Appl. No.:

12/770570

Inventors:

Gregory H. Altman - Arlington MA, US
David L. Kaplan - Concord MA, US
Rebecca Horan - Arlington MA, US
David J. Horan - Westfield MA, US

Assignee:

ALLERGAN, INC. - Irvine CA

International Classification:

A61K 35/12
C07K 14/47
A61K 47/42
D02G 3/02
A61K 35/32
A61K 35/34
A61P 19/00

US Classification:

424 937, 530353, 514773, 428401

Abstract:

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

US Patent:

20100256756, Oct 7, 2010

Filed:

Apr 29, 2010

Appl. No.:

12/770588

Inventors:

Gregory H. Altman - Arlington MA, US
Jingsong Chen - Virginia Beach VA, US
Rebecca Horan - Arlington MA, US
David J. Horan - Westfield MA, US

Assignee:

ALLERGAN, INC. - Irvine CA

International Classification:

A61F 2/08
A61F 2/02

US Classification:

623 132, 623 2372

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.