David C Horan

US Patent:

6383589, May 7, 2002

Filed:

Mar 29, 1999

Appl. No.:

09/280623

Inventors:

David C. Horan - Appleton WI
Thomas R. Lee - Appleton WI

Assignee:

Pechiney Plastic Packaging, Inc. - Chicago IL

International Classification:

B32B 108

US Classification:

428 3691, 428 357, 428168, 220 92, 220107

Abstract:

An improved coextruded asymmetric multilayer plastic structure and method of forming the same are provided. The layers of the structure consist of a barrier layer comprised of an ethylene vinyl alcohol copolymer, an adhesive layer on each surface of the barrier layer, inner and outer surface layers, and a bulk layer positioned between the outer surface layer and its adjacent adhesive layers. The bulk layer is comprised of a thermoplastic polymer and calcium carbonate in an amount sufficient that the multilayer structure has an acceptable level of curling. The structure can be used to form a tubular body that has a cylindrical shape. A collapsible dispensing container having a body wall formed of the aforementioned structure and having improved product dispense properties is also provided.

US Patent:

6902932, Jun 7, 2005

Filed:

Nov 16, 2001

Appl. No.:

10/008924

Inventors:

Gregory H. Altman - Dedham MA, US
David L. Kaplan - Concord MA, US
Rebecca L. Horan - Westfield MA, US
David J. Horan - Westfield MA, US

Assignee:

Tissue Regeneration, Inc. - Medford MA
Trustees of Tufts College - Medford MA

International Classification:

C12N005/06
C12N005/08
C12N011/08
C12N011/04
A61F002/00

US Classification:

435395, 424423, 424 937, 435177, 435180, 435182

Abstract:

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

US Patent:

8172901, May 8, 2012

Filed:

Mar 20, 2008

Appl. No.:

12/052719

Inventors:

Gregory H. Altman - Arlington MA, US
Enrico Mortarino - Hickory NC, US
David J. Horan - Westfield MA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

A61F 2/08

US Classification:

623 1312, 623 1311

Abstract:

A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from in-growth.

US Patent:

8623398, Jan 7, 2014

Filed:

Jul 30, 2012

Appl. No.:

13/561808

Inventors:

Gregory H. Altman - Arlington MA, US
Rebecca Horan - Arlington MA, US
David J. Horan - Westfield MA, US
Jingsong Chen - Virginia Beach VA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

A61F 2/00
C12N 11/02
C12N 5/07

US Classification:

424426, 435177, 435399

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e. g. , twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

US Patent:

8628791, Jan 14, 2014

Filed:

Mar 24, 2011

Appl. No.:

13/071396

Inventors:

Gregory H. Altman - Arlington MA, US
Jingson Chen - Virginia Beach VA, US
Rebecca L. Horan - Arlington MA, US
David J. Horan - Westfield MA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

A61F 2/00
C12N 11/02
C12N 5/00
C12N 5/07

US Classification:

424423, 435177, 435 398, 435399

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e. g. , twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

US Patent:

20040224406, Nov 11, 2004

Filed:

Mar 11, 2004

Appl. No.:

10/800134

Inventors:

Gregory Altman - Dedham MA, US
Jingsong Chen - Malden MA, US
Rebecca Horan - Westfield MA, US
David Horan - Westfield MA, US

Assignee:

Tissue Regeneration, Inc. - Medford MA

International Classification:

C12N005/02
B32B027/04

US Classification:

435/395000, 442/128000

Abstract:

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

US Patent:

20050089552, Apr 28, 2005

Filed:

Nov 16, 2004

Appl. No.:

10/990199

Inventors:

Gregory Altman - Dedham MA, US
David Kaplan - Concord MA, US
Rebecca Horan - Westfield MA, US
David Horan - Westfield MA, US

Assignee:

Tissue Regeneration, Inc. - Medford MA
Trustees of Tufts College - Medford MA

International Classification:

A61F002/08
A61K038/17
C07K014/435

US Classification:

424445000, 623013170, 623013190, 435395000, 530353000

Abstract:

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

US Patent:

20100209405, Aug 19, 2010

Filed:

Apr 29, 2010

Appl. No.:

12/770570

Inventors:

Gregory H. Altman - Arlington MA, US
David L. Kaplan - Concord MA, US
Rebecca Horan - Arlington MA, US
David J. Horan - Westfield MA, US

Assignee:

ALLERGAN, INC. - Irvine CA

International Classification:

A61K 35/12
C07K 14/47
A61K 47/42
D02G 3/02
A61K 35/32
A61K 35/34
A61P 19/00

US Classification:

424 937, 530353, 514773, 428401

Abstract:

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

Address:

425 W Spg St, Appleton, WI 54911

VIN:

JTMBK31V59D005036

Make:

TOYOTA

Model:

RAV4

Year:

2009