David S Hunter

US Patent:

20180179190, Jun 28, 2018

Filed:

Jun 24, 2016

Appl. No.:

15/737334

Inventors:

- Rahway NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Alexander Pasternak - Princeton NJ, US
Shuzhi Dong - Plainsboro NJ, US
Xin Gu - Scotch Plains NJ, US
Jack D. Scott - Scotch Plains NJ, US
Haiqun Tang - Belle Mead NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Yuhua Huang - Westfield NJ, US
David Hunter - Hatfield PA, US
Dexi Yang - Livingston NJ, US
Katherine Young - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Zhibo Zhang - Beijing, CN
Jianmin Fu - Beijing, CN
Yunfeng Bai - Beijing, CN
Zhixiang Zheng - Beijing, CN
Xu Zhang - Beijing, CN

Assignee:

Marck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 403/14
A61K 45/06
A61K 31/4184
C07D 401/14
A61K 31/454
C07D 471/04
A61K 31/437
A61K 31/4545
C07D 487/04
A61K 31/5025
C07D 403/10
A61K 31/416
A61K 31/4439
C07D 417/14
A61K 31/428
A61K 31/4375
C07D 413/14
A61K 31/423
A61K 31/4709
A61K 31/4725
A61K 31/517
A61K 31/506
A61K 31/498
A61K 31/5377
A61P 31/04

Abstract:

The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, R, X, Xand Rare as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

US Patent:

20160333021, Nov 17, 2016

Filed:

Jan 16, 2015

Appl. No.:

15/110431

Inventors:

- Rahway NJ, US
Haifeng Tang - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Jing Su - Scotch Plains NJ, US
Guoqing Li - Belle Mead NJ, US
Shu-Wei Yang - Edison NJ, US
Weidong Pan - Hillsborough NJ, US
Haiqun Tang - Belle Mead NJ, US
Reynalda DeJesus - East Brunswick NJ, US
Jacqueline Hicks - Scotch Plains NJ, US
Matthew Lombardo - Flemington NJ, US
Hong Chu - Livingston NJ, US
William Hagmann - Westfield NJ, US
Alex Pasternak - Princeton NJ, US
Xin Gu - Scotch Plains NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Shuzhi Dong - Plainsboro NJ, US
Clare London - Chatham NJ, US
Dipshikha Biswas - Woodbridge NJ, US
Katherine Young - Metuchen NJ, US
David N. Hunter - Scotch Plains NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Dexi Yang - Livingston NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 491/048
A61K 31/41
A61K 45/06
A61K 31/407
A61K 31/197
C07D 405/12
A61K 31/5377
C07D 403/10
A61K 31/4192
A61K 31/496
C07D 401/10
A61K 31/454
A61K 31/4439
C07D 409/10
C07D 417/10
A61K 31/427
C07D 405/14
C07D 413/10
A61K 31/422
A61K 31/506
A61K 31/497
A61K 31/4178
A61K 31/501
A61K 31/4155
C07D 471/04
A61K 31/437
C07D 417/14
C07D 401/14
C07D 487/04
A61K 31/5025
A61K 31/4245
A61K 31/541
C07D 401/04
C07D 413/14
A61K 31/55
C07D 471/10
C07D 257/04

Abstract:

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

US Patent:

20160303244, Oct 20, 2016

Filed:

Jun 24, 2016

Appl. No.:

15/191584

Inventors:

- Rahway NJ, US
Lin Yan - East Brunswick NJ, US
Ahmet Kekec - Hoboken NJ, US
Yuping Zhu - Basking Ridge NJ, US
David N. Hunter - Scotch Plains NJ, US
Pei Huo - Millburn NJ, US
Danqing Feng - Green Brook NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Christopher R. Moyes - Westfield NJ, US
Zhiqiang Zhao - Rahway NJ, US
Brenda Pipik - Edison NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Erin N. Guidry - Cranford NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 47/48
C07K 14/62
A61K 38/28

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

US Patent:

20160251407, Sep 1, 2016

Filed:

Oct 2, 2014

Appl. No.:

15/025912

Inventors:

Songnian LIN - Kenilworth NJ, US
Lin YAN - Kenilworth NJ, US
Ahmet KEKEC - Kenilworth NJ, US
Yuping ZHU - Kenilworth NJ, US
David N. HUNTER - Kenilworth NJ, US
Pei HUO - Kenilworth NJ, US
Danqing FENG - Kenilworth NJ, US
Ravi P. NARGUND - Kenilworht NJ, US
Christopher R. MOYES - Kenilworth NJ, US
Zhiqiang ZHAO - Kenilworth NJ, US
Brenda PIPIK - Edison NJ, US
Dimitri PISSARNITSKI - Kenilworth NJ, US
Joseph L. DUFFY - Rahway NJ, US
Erin N. GUIDRY - Kenilworth NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07K 14/62
A61K 38/28
A61K 47/48

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

US Patent:

20150105317, Apr 16, 2015

Filed:

Oct 2, 2014

Appl. No.:

14/504476

Inventors:

- Rahway NJ, US
Lin Yan - East Brunswick NJ, US
Ahmet Kekec - Hoboken NJ, US
Yuping Zhu - Basking Ridge NJ, US
David N. Hunter - Scotch Plains NJ, US
Pei Huo - Millburn NJ, US
Danqing Feng - Greenbrook NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Christopher R. Moyes - Westfield NJ, US
Zhiqiang Zhao - Rahway NJ, US
Brenda Pipik - Edison NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Erin N. Guidry - Cranford NJ, US

International Classification:

A61K 47/48
A61K 38/28

US Classification:

514 59, 530399

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.