David H Kummer

US Patent:

20170258782, Sep 14, 2017

Filed:

Mar 14, 2016

Appl. No.:

15/069030

Inventors:

- Beerse, BE
Kent Barbay - Flourtown PA, US
James P. Edwards - San Diego CA, US
Kevin D. Kreutter - Plainsboro NJ, US
David A. Kummer - San Diego CA, US
Umar Maharoof - North Wales PA, US
Rachel Nishimura - San Diego CA, US
Maud Urbanski - Flemington NJ, US
Hariharan Venkatesan - San Diego CA, US
Aihua Wang - Jamison PA, US
Ronald L. Wolin - San Diego CA, US
Craig R. Woods - San Diego CA, US
Anne Fourie - San Diego CA, US
Xiaohua Xue - San Diego CA, US
Maxwell D. Cummings - Ambler PA, US

International Classification:

A61K 31/4709

Abstract:

The present invention comprises compounds of Formula I.wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20160279122, Sep 29, 2016

Filed:

Jun 14, 2016

Appl. No.:

15/182231

Inventors:

- Beerse, BE
Kent Barbay - Flourtown PA, US
James P. Edwards - San Diego CA, US
Kevin D. Kreutter - Plainsboro NJ, US
David A. Kummer - San Diego CA, US
Umar Maharoof - North Wales PA, US
Rachel Nishimura - San Diego CA, US
Maud Urbanski - Flemington NJ, US
Hariharan Venkatesan - San Diego CA, US
Aihua Wang - Jamison PA, US
Ronald L. Wolin - San Diego CA, US
Craig R. Woods - San Diego CA, US
Anne Fourie - San Diego CA, US
Xiaohua Xue - San Diego CA, US
Maxwell D. Cummings - Ambler PA, US

International Classification:

A61K 31/4709
A61K 45/06
A61K 31/506

Abstract:

The present invention comprises compounds of Formula I.wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20160136149, May 19, 2016

Filed:

Jan 22, 2016

Appl. No.:

15/004048

Inventors:

- Beerse, BE
Kent Barbay - Flourtown PA, US
James P. Edwards - San Diego CA, US
Kevin D. Kreutter - Plainsboro NJ, US
David A. Kummer - San Diego CA, US
Umar Maharoof - North Wales PA, US
Rachel Nishimura - San Diego CA, US
Maud Urbanski - Flemington NJ, US
Hariharan Venkatesan - San Diego CA, US
Aihua Wang - Jamison PA, US
Ronald L. Wolin - San Diego CA, US
Craig R. Woods - San Diego CA, US
Anne Fourie - San Diego CA, US
Xiaohua Xue - San Diego CA, US
Maxwell D. Cummings - Ambler PA, US

Assignee:

Janssen Pharmaceutica NV - New Brunswick NJ

International Classification:

A61K 31/4709
A61K 45/06

Abstract:

The present invention comprises compounds of Formula I.wherein:R, R, R, R, R, R, RR, and Rare defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20150105365, Apr 16, 2015

Filed:

Oct 15, 2013

Appl. No.:

14/053736

Inventors:

- Beerse, BE
Kent Barbay - Flourtown PA, US
James P. Edwards - San Diego CA, US
Kevin D. Kreutter - Plainsboro NJ, US
David A. Kummer - San Diego CA, US
Umar Maharoof - North Wales PA, US
Rachel Nishimura - San Diego CA, US
Maud Urbanski - Flemington NJ, US
Hariharan Venkatesan - San Diego CA, US
Aihua Wang - Jamison PA, US
Ronald L. Wolin - San Diego CA, US
Craig R. Woods - San Diego CA, US
Anne Fourie - San Diego CA, US
Xiaohua Xue - San Diego CA, US
Maxwell D. Cummings - Ambler PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 401/14
C07D 401/12
A61K 45/06
A61K 31/4709

US Classification:

51421002, 51421021, 514312, 540362, 546153

Abstract:

The present invention comprises compounds of Formula I.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20150105366, Apr 16, 2015

Filed:

Oct 15, 2013

Appl. No.:

14/053797

Inventors:

- Beerse, BE
Kent Barbay - Flourtown PA, US
James P. Edwards - San Diego CA, US
Kevin D. Kreutter - Plainsboro NJ, US
David A. Kummer - San Diego CA, US
Umar Maharoof - North Wales PA, US
Rachel Nishimura - San Diego CA, US
Maud Urbanski - Flemington NJ, US
Hariharan Venkatesan - San Diego CA, US
Aihua Wang - Jamison PA, US
Ronald L. Wolin - San Diego CA, US
Craig R. Woods - San Diego CA, US
Anne Fourie - San Diego CA, US
Xiaohua Xue - San Diego CA, US
Maxwell D. Cummings - Ambler PA, US
William Moore Jones - San Diego CA, US
Steven Goldberg - Encinitas CA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 417/14
A61K 31/4709
A61K 45/06
C07D 413/14
C07D 409/14
C07D 401/06
A61K 31/506
A61K 31/5377
C07D 405/14
C07D 401/14

US Classification:

51421018, 546157, 514312, 546176, 514314, 546175, 546172, 544333, 514256, 51421021, 546153, 546159, 514313, 544128, 5142352

Abstract:

The present invention comprises compounds of Formula I.wherein:The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20150105369, Apr 16, 2015

Filed:

Oct 14, 2014

Appl. No.:

14/513455

Inventors:

- BEERSE, BE
KENT BARBAY - FLOURTOWN PA, US
JAMES P. EDWARDS - SAN DIEGO CA, US
KEVIN D. KREUTTER - PLAINSBORO NJ, US
DAVID A. KUMMER - SAN DIEGO CA, US
UMAR MAHAROOF - NORTH WALES PA, US
RACHEL NISHIMURA - SAN DIEGO CA, US
MAUD URBANSKI - FLEMINGTON NJ, US
HARIHARAN VENKATESAN - SAN DIEGO CA, US
AIHUA WANG - JAMISON PA, US
RONALD L. WOLIN - SAN DIEGO CA, US
CRAIG R. WOODS - SAN DIEGO CA, US
ANNE FOURIE - SAN DIEGO CA, US
XIAOHUA XUE - SAN DIEGO CA, US
MAXWELL D. CUMMINGS - AMBLER PA, US

International Classification:

C07D 401/06
C07D 417/06
C07D 413/06

US Classification:

51421018, 546173, 514314, 546172, 546157, 514312, 51421021

Abstract:

The present invention comprises compounds of Formula I.wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20150105372, Apr 16, 2015

Filed:

Oct 15, 2013

Appl. No.:

14/053906

Inventors:

- BEERSE, BE
KENT BARBAY - FLOURTOWN PA, US
JAMES P. EDWARDS - SAN DIEGO CA, US
KEVIN D. KREUTTER - PLAINSBORO NJ, US
DAVID A. KUMMER - SAN DIEGO CA, US
UMAR MAHAROOF - NORTH WALES PA, US
RACHEL NISHIMURA - SAN DIEGO CA, US
MAUD URBANSKI - FLEMINGTON NJ, US
HARIHARAN VENKATESAN - SAN DIEGO CA, US
AIHUA WANG - JAMISON PA, US
RONALD L. WOLIN - SAN DIEGO CA, US
CRAIG R. WOODS - SAN DIEGO CA, US
ANNE FOURIE - SAN DIEGO CA, US
XIAOHUA XUE - SAN DIEGO CA, US
MAXWELL D. CUMMINGS - AMBLER PA, US

Assignee:

JANSSEN PHARMACEUTICA NV - BEERSE

International Classification:

C07D 413/06
A61K 45/06
A61K 31/47
C07D 401/14
C07D 215/227
A61K 31/4709
C07D 401/06

US Classification:

51421021, 546173, 514314, 546157, 514312, 546159, 514311

Abstract:

The present invention comprises compounds of Formula I.wherein:The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

US Patent:

20150105404, Apr 16, 2015

Filed:

Oct 15, 2013

Appl. No.:

14/053773

Inventors:

- Beerse, BE
Kent Barbay - Flourtown PA, US
James P. Edwards - San Diego CA, US
Kevin D. Kreutter - Plainsboro NJ, US
David A. Kummer - San Diego CA, US
Umar Maharoof - North Wales PA, US
Rachel Nishimura - San Deigo CA, US
Maud Urbanski - Flemington NJ, US
Hariharan Venkatesan - San Deigo CA, US
Aihua Wang - Jamison PA, US
Ronald L. Wolin - San Diego CA, US
Craig R. Woods - San Diego CA, US
Anne Fourie - San Diego CA, US
Xiaohua Xue - San Diego CA, US
Maxwell D. Cummings - Ambler PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 417/14
C07D 409/14
C07D 401/06
C07D 401/14

US Classification:

514256, 546157, 514312, 544333, 546167, 514314, 544316, 514274, 546159, 514313

Abstract:

The present invention comprises compounds of Formula I.wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim