David Ha Lieberman

US Patent:

6340229, Jan 22, 2002

Filed:

Apr 11, 2001

Appl. No.:

09/762504

Inventors:

David M. Lieberman - New York NY
Jonathon Grierson - Atwater OH

Assignee:

Scientific Optics, Inc. - New York NY

International Classification:

G02C 704

US Classification:

351160R

Abstract:

A contact lens that reduces power distortion and lens contact with the corneal surface resulting from lens flexure. The contact lens ( ) is designed to include a central optical portion, a scleral skirt ( ), and a transition portion ( ) therebetween, overlying the cornea, the posterior surface of which is conformed to the local geometry of the underlying portion of the cornea, including corneal tilt and distortion. In an alternative embodiment representing a less expensive lens, the transition portion is designed to conform to a statistically average cornea. The central optical portion may have a posterior surface which is customized, is toric or spherical, depending on whether a custom or inexpensive soft lens is being designed.

US Patent:

6416179, Jul 9, 2002

Filed:

Sep 19, 2000

Appl. No.:

09/646739

Inventors:

David M. Lieberman - New York NY
Jonathon Grierson - Atwater OH

Assignee:

Scientific Optics, Inc. - New York NY

International Classification:

A61B 310

US Classification:

351212, 606 5, 351219

Abstract:

Methods, and apparatus are disclosed for performing corneal ablation procedures of the eye ( ) in a manner which does not interfere with the natural shape of the cornea or its orientation relative to the remainder of the eye, but which changes its surface curvature appropriately to achieve the required correction of vision. Three preferred embodiments are described, which model the cornea to different degrees of accuracy. Once the model of the cornea is obtained ( ), surface curvature is modified ( ) to achieve the degree of correction in refraction that is necessary, as determined by an eye test of the patient. The modified model of the cornea is then utilized to control the removal of material from the surface of the cornea in a corneal ablation operation.

US Patent:

6552166, Apr 22, 2003

Filed:

Oct 18, 2000

Appl. No.:

09/691523

Inventors:

Joseph E. Lynch - Plainfield NJ
Michael A. Robbins - Short Hills NJ
David R. Lieberman - Jersey City NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07K 110

US Classification:

530322, 530338, 530345

Abstract:

The present invention is directed to the improved synthesis of compounds of formula I: which may be useful in the treatment of prostate cancer. Such compounds are synthesized in the presence of a carboxyl activating agent, an additive and a base for the preparation of a PSA conjugate which comprises an anthracycline antibiotic and an oligopeptide.

US Patent:

6599285, Jul 29, 2003

Filed:

Aug 8, 2000

Appl. No.:

09/634336

Inventors:

David Lieberman - New York NY
Jonathan Grierson - Atwater OH

Assignee:

Scientific Optics, Inc. - New York NY

International Classification:

A61B 1732

US Classification:

606 5, 606166, 600587

Abstract:

Methods and apparatus are disclosed for causing the optical center of the eye to align âHIGH pointâ of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a âbounded region. â For corneal ablation procedures, the âbounded regionâ comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a âgreat circleâ are formed in the cornea to weaken and flatten it. As used herein, a âgreat circleâ is formed by a plane containing the HIGH point and parallel to the local z-axis.

US Patent:

6669342, Dec 30, 2003

Filed:

May 22, 2002

Appl. No.:

10/154412

Inventors:

David M. Lieberman - New York NY
Jonathon Grierson - Atwater OH

Assignee:

Scientific Optics, Inc. - New York NY

International Classification:

A61B 310

US Classification:

351212

Abstract:

Methods, and apparatus are disclosed for performing corneal ablation procedures of the eye ( ) in a manner which does not interfere with the natural shape of the cornea or its orientation relative to the remainder of the eye, but which changes its surface curvature appropriately to achieve the required correction of vision. Three preferred embodiments are described, which model the cornea to different degrees of accuracy. Once the model of the cornea is obtained ( ), surface curvature is modified ( ) to achieve the degree of correction in refraction that is necessary, as determined by an eye test of the patient. The modified model of the cornea is then utilized to control the removal of material from the surface of the cornea in a corneal ablation operation.

US Patent:

7338160, Mar 4, 2008

Filed:

May 27, 2004

Appl. No.:

10/558509

Inventors:

David M. Lieberman - New York NY, US
Jonathan Grierson - Atwater OH, US

Assignee:

Scientific Optics, Inc. c/o Avalon Ventures - La Jolla CA

International Classification:

G02C 7/04

US Classification:

351160R, 351177

Abstract:

Eye measurements taken on a patient being fitted for contact lens will include a refraction test and an additional measurement representing corneal depth variation on the surface of an imaginary cylinder having the same diameter as the lens. This information then used during lens manufacture to produce lens in which the perimeter is not circular and does not lie in a plane, but which drops backwards towards the eye at appropriate points to produce a saddle-shaped perimeter.

US Patent:

7736003, Jun 15, 2010

Filed:

Sep 28, 2007

Appl. No.:

12/305279

Inventors:

David M. Lieberman - New York NY, US
Jonathan Grierson - Atwater OH, US

Assignee:

Scientific Optics, Inc. - La Jolla CA

International Classification:

A61B 3/00
A61B 3/10
A61B 18/18

US Classification:

351246, 351212, 606 5

Abstract:

Certain disorders of the cornea exhibit unique characteristics in a surface model of the cornea. Through various manipulations of the characteristics of the surface model of a patient's cornea, certain “markers” that are associated with disorders of the eye may be revealed.

US Patent:

7871163, Jan 18, 2011

Filed:

Jan 12, 2010

Appl. No.:

12/685759

Inventors:

David M. Lieberman - New York NY, US
Jonathan Grierson - Atwater OH, US

Assignee:

Scientific Optics, Inc. - New York NY

International Classification:

G02C 7/02
G02C 7/04
A61B 18/18

US Classification:

351177, 351160 R, 606 5

Abstract:

“Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea.