David C Lynn

US Patent:

6998115, Feb 14, 2006

Filed:

Oct 2, 2001

Appl. No.:

09/969431

Inventors:

Robert S. Langer - Newton MA, US
David M. Lynn - Somerville MA, US
David Putnam - Cambridge MA, US
Mansoor M. Amiji - Attleboro MA, US
Daniel G. Anderson - Framingham MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/765
C08G 69/44
C08G 63/44
C07C 327/00

US Classification:

424 7837, 528288, 528362, 564 78

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

US Patent:

7427394, Sep 23, 2008

Filed:

May 28, 2003

Appl. No.:

10/446444

Inventors:

Daniel G. Anderson - Framingham MA, US
David M. Lynn - Middleton WI, US
Akin Akinc - Newton MA, US
Robert S. Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The United States of Americas as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 31/765
C08G 69/44
C08G 63/44
C07C 327/00

US Classification:

424 7837, 528288, 528362, 564 78

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.

US Patent:

7943179, May 17, 2011

Filed:

Dec 2, 2004

Appl. No.:

11/002542

Inventors:

Steven R. Little - Somerville MA, US
David M. Lynn - Middleton WI, US
Daniel G. Anderson - Framingham MA, US
Robert S. Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 9/16

US Classification:

424490

Abstract:

A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the inventive pH triggerable particles. Upon exposure to an acidic environment such as the endosome or phagosome of a cell, the particles dissolve or disrupt due to protonation or an increase in solubility of the pH triggering agent. Pharmaceutical compositions and methods of preparing and administering these particles are also described. These particles may be particularly useful in genetic vaccination.

US Patent:

8105652, Jan 31, 2012

Filed:

Jul 26, 2006

Appl. No.:

11/459979

Inventors:

Kris C. Wood - Cambridge MA, US
Helen F. Chuang - Cambridge MA, US
Robert D. Batten - Princeton NJ, US
David M. Lynn - Middleton WI, US
Paula T. Hammond Cunningham - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

B32B 7/02
A61F 2/00
A61K 9/00
A61K 9/52

US Classification:

427331, 428212, 428402, 4284022, 42840221, 42840222, 42840224, 428430, 428480, 428483, 428702, 428426, 428446, 428454, 428457, 427 21, 427212, 427214, 427340, 4274071, 424426, 424443, 424484, 424489, 424 7808

Abstract:

A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.

US Patent:

RE43612, Aug 28, 2012

Filed:

Sep 28, 2009

Appl. No.:

12/568481

Inventors:

Daniel Griffith Anderson - Sudbury MA, US
David M. Lynn - Middleton WI, US
Akin Akinc - Needham MA, US
Robert S. Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/765
C08G 69/44
C08G 63/44
C07C 327/00

US Classification:

424 7837, 528288, 528362, 564 78

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.

US Patent:

8287849, Oct 16, 2012

Filed:

Jul 23, 2009

Appl. No.:

12/507999

Inventors:

Robert S. Langer - Newton MA, US
David M. Lynn - Somerville MA, US
David Putnam - Cambridge MA, US
Mansoor M. Amiji - Attleboro MA, US
Daniel G. Anderson - Framingham MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/765
A61K 9/00
C08F 26/00

US Classification:

424 7837, 424400, 526312

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

US Patent:

8557231, Oct 15, 2013

Filed:

Apr 6, 2005

Appl. No.:

11/099886

Inventors:

Robert S. Langer - Newton MA, US
David M. Lynn - Somerville MA, US
David Putnam - Cambridge MA, US
Mansoor M. Amiji - Attleboro MA, US
Daniel G. Anderson - Framingham MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/785
A61K 31/765
C08G 69/08

US Classification:

424 7836, 424 7837, 528310

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

US Patent:

20060083711, Apr 20, 2006

Filed:

Apr 15, 2005

Appl. No.:

11/107360

Inventors:

David Berry - Brookline MA, US
Daniel Anderson - Framingham MA, US
David Lynn - Madison WI, US
Ram Sasisekharan - Bedford MA, US
Robert Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/785
A61K 31/737
A61K 31/727

US Classification:

424078120, 514054000, 514056000

Abstract:

The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates to the use of glycosaminoglycans for the treatment of proliferative disorders, such as cancer. The invention is still other aspects relates to improving cell viability. The invention also relates to the delivery of polysaccharides while avoiding unwanted effects of the polysaccharides. For example, heparin can be delivered while avoiding its anticoagulant effects.