David M Lynn

US Patent:

6376690, Apr 23, 2002

Filed:

Aug 30, 1999

Appl. No.:

09/386205

Inventors:

Robert H. Grubbs - Pasadena CA
Heather D. Maynard - Pasadena CA
David M. Lynn - Somerville MA

Assignee:

California Institute O Technology - Pasadena CA

International Classification:

C07F 1500

US Classification:

556 21, 556136

Abstract:

The present invention generally relates to the discovery that the solubility of metal complexes may be readily manipulated by the addition of one or more solubility-enhancing compounds. This manipulation of the solubilities allows for the preparation of suitable samples for precise quantitative analysis and for the facile purification of the desired products from the reaction mixture containing one or more metal complexes. In one embodiment of the invention, the relative solubilities between two solutions are manipulated so as cause the metal complex found in a first solution to transfer to a second solution that is generally immiscible with the first solution. The metal complex is thus separated from the reaction mixture which comprises the first solution by the removal of the second solution. In another embodiment, the solubility-enhancing compounds of the present invention is used to prepare samples containing metal complexes for precise quantitative analysis such as inductively coupled plasma mass spectroscopy.

US Patent:

6486279, Nov 26, 2002

Filed:

Jun 14, 2001

Appl. No.:

09/882776

Inventors:

David M. Lynn - Pasadena CA
Eric L. Dias - Chapel Hill NC
Robert H. Grubbs - South Pasadena CA
Bernard Mohr - Heidelberg, DE

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C08G 6106

US Classification:

526171, 526 92, 526135, 526145, 526146, 526259, 526268, 526281, 526283, 526308, 526309, 526335, 526336, 525269, 525289, 525290, 525297, 26433113, 26433115

Abstract:

Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-methasis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula A L X Ru CHRâ where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where Râ is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.

US Patent:

6998115, Feb 14, 2006

Filed:

Oct 2, 2001

Appl. No.:

09/969431

Inventors:

Robert S. Langer - Newton MA, US
David M. Lynn - Somerville MA, US
David Putnam - Cambridge MA, US
Mansoor M. Amiji - Attleboro MA, US
Daniel G. Anderson - Framingham MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 31/765
C08G 69/44
C08G 63/44
C07C 327/00

US Classification:

424 7837, 528288, 528362, 564 78

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

US Patent:

7112361, Sep 26, 2006

Filed:

Oct 24, 2002

Appl. No.:

10/280268

Inventors:

David M. Lynn - Middleton WI, US
Eduardo Vazquez - Bayamon PR, US
Robert Langer - Newton MA, US
Paula T. Hammond - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

B32B 7/02

US Classification:

428212, 428402, 4284022, 42840221, 42840222, 42840224, 428403, 428480, 428483, 428702, 428426, 428446, 428454, 428457

Abstract:

A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.

US Patent:

7291693, Nov 6, 2007

Filed:

Jun 25, 2002

Appl. No.:

10/180000

Inventors:

Venkatram Prasad Shastri - Lower Gwynedd PA, US
Alexander Zelikin - Moscow, RU
David Lynn - Middleton WI, US
Robert S. Langer - Newton MA, US
Ivan Martin - Oberwil, CH

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C08G 73/06

US Classification:

528423, 528424, 528271, 528287, 528293

Abstract:

The present invention specifically contemplates a polymer, preferably an electrically conductive polymer, derived from substituted pyrrolyl moieties.

US Patent:

7427394, Sep 23, 2008

Filed:

May 28, 2003

Appl. No.:

10/446444

Inventors:

Daniel G. Anderson - Framingham MA, US
David M. Lynn - Middleton WI, US
Akin Akinc - Newton MA, US
Robert S. Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The United States of Americas as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 31/765
C08G 69/44
C08G 63/44
C07C 327/00

US Classification:

424 7837, 528288, 528362, 564 78

Abstract:

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.

US Patent:

7883720, Feb 8, 2011

Filed:

Jul 7, 2004

Appl. No.:

10/886161

Inventors:

David M. Lynn - Middleton WI, US
Adam D. Miller - Berkeley CA, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61K 9/00
C12N 15/00
C08F 283/06
A61K 47/00

US Classification:

424450, 4242801, 424452, 424486, 424487, 424489, 424499, 435 6, 435 691, 435455, 435458, 435459, 435463, 435465, 514 44, 514 54, 5147721, 5147722, 5147723

Abstract:

The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.

US Patent:

7943179, May 17, 2011

Filed:

Dec 2, 2004

Appl. No.:

11/002542

Inventors:

Steven R. Little - Somerville MA, US
David M. Lynn - Middleton WI, US
Daniel G. Anderson - Framingham MA, US
Robert S. Langer - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 9/16

US Classification:

424490

Abstract:

A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the inventive pH triggerable particles. Upon exposure to an acidic environment such as the endosome or phagosome of a cell, the particles dissolve or disrupt due to protonation or an increase in solubility of the pH triggering agent. Pharmaceutical compositions and methods of preparing and administering these particles are also described. These particles may be particularly useful in genetic vaccination.