David A Ott

US Patent:

7678833, Mar 16, 2010

Filed:

May 23, 2007

Appl. No.:

11/805637

Inventors:

David M. Ott - Oakland CA, US

Assignee:

Allium Vitalis Incorporated - Berkeley CA

International Classification:

A23L 1/30
A61K 31/10
A61K 38/02

US Classification:

514706, 424439, 426547, 426648, 514 2, 514707

Abstract:

A method for increasing the bioavailability of cysteine within an animal by reducing extracellular cysteine disulfide molecules to produce extracellular cysteine molecules. A membrane permeable thiol molecule that forms a membrane permeable disulfide molecule after becoming oxidized participates in thiol-disulfide exchange reactions on both sides of the cellular membrane, crossing the membrane randomly via simple diffusion. The membrane permeable disulfide, within or upon entering the highly reductive environment of a cell, becomes reduced to form a membrane permeable thiol molecule. the membrane permeable thiol can then diffuse to the exterior of the cell, where it is available to reduce another cystine molecule. This process can continue cycling, producing net cumulative increase in the concentration of extracellular cysteine. This is beneficial for providing cysteine as a nutrient to cells that require cysteine for nourishment.

US Patent:

8217084, Jul 10, 2012

Filed:

May 24, 2005

Appl. No.:

11/137747

Inventors:

David M. Ott - Oakland CA, US

Assignee:

Allium Vitalis Incorporated - Berkeley CA

International Classification:

A23L 1/30
A61K 31/10
A61K 38/02

US Classification:

514706, 514707, 514 11, 424439, 426547, 426648

Abstract:

Nutraceutical and dietary supplement formulations for delivering bioavailable thiols to a host, comprising certain organosulfur radicals, such as the allyl mercapto radical, bound to larger molecules such as proteins, resulting in the formation in the host's body of various -related compounds such as allicin. The formulations are produced by treating an ingestible material comprising a cysteine-containing protein with a thiol, disulfide, mixed disulfide, thiosufinate or mixed thiosulfinate so as to cause thiol residues to become disulfide bonded to cysteines contained in the protein.

US Patent:

8222299, Jul 17, 2012

Filed:

May 24, 2004

Appl. No.:

10/853415

Inventors:

David M. Ott - Oakland CA, US

Assignee:

Allium Vitalis Incorporated - Berkeley CA

International Classification:

A61K 31/095

US Classification:

514706

Abstract:

A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to simultaneously enhance the host's ability to eliminate infectious microbes while suppressing the toxicity of the immune system response to the host. Allium related organosulfur compounds have a variety of antimicrobial and immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium related organosulfur compound such that a localized thiosulfinate is caused to be formed in response to localized generation of reactive oxygen species such as hydrogen peroxide by the activated immune system cells. Allium related organosulfur compounds may be administered to the host in an efficient manner through the use of protein-bound S-AllylMercaptoCysteine or similar prodrugs.

US Patent:

20060269488, Nov 30, 2006

Filed:

May 24, 2006

Appl. No.:

11/441292

Inventors:

David Ott - Oakland CA, US

International Classification:

A61K 8/18

US Classification:

424049000

Abstract:

Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-microbial, anti-oxidant, anti-inflammatory, and anti-aging properties and are suitable for use without a prescription. The products utilize a biomembrane permeable organosulfur compound that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to oxidants and antioxidants inside and outside of cells. Example products include an anti-microbial toothpaste with anti-plaque properties, an anti-inflammatory skin lotion with antioxidant, antimicrobial, and deodorant properties, and an anti-toxin skin lotion with anti-arsenicosis properties.

US Patent:

20120295977, Nov 22, 2012

Filed:

Jun 20, 2012

Appl. No.:

13/507307

Inventors:

David M. Ott - Oakland CA, US

International Classification:

A61K 31/095
A61P 11/00
A61P 29/00
A61K 31/198
A61P 31/00

US Classification:

514562, 514706

Abstract:

A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to enhance the host's ability to eliminate infectious microbes while simultaneously suppressing the toxicity of the immune system response to the host. Allium related organosulfur compounds are disclosed which have a various antimicrobial immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium related organosulfur compound such that a localized thiosulfinate is caused to be non-enzymatically formed in response to localized generation by activated immune system cells of reactive oxygen species such as hydrogen peroxide. Suitable allium related organosulfur compounds may be administered to the host in an efficient manner through the use of S-AllylMercapto-N-AcetylCysteine (SAMNAC) or similar prodrugs.

US Patent:

20130143967, Jun 6, 2013

Filed:

Dec 5, 2011

Appl. No.:

13/373878

Inventors:

David M. Ott - Oakland CA, US

International Classification:

A61K 31/198
A61P 25/00
A61P 25/16
C07C 321/18
A61P 25/28

US Classification:

514562, 562557

Abstract:

S-allylmercapto-N-acetylcysteine and related compounds are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compounds include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.

US Patent:

20130149256, Jun 13, 2013

Filed:

Nov 16, 2012

Appl. No.:

13/694304

Inventors:

David Michael Ott - Oakland CA, US

International Classification:

A61K 8/46
A61Q 11/00

US Classification:

424 49

Abstract:

Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-microbial, anti-oxidant, anti-inflammatory, and anti-aging properties and are suitable for use without a prescription. The products utilize a biomembrane permeable organosulfur compound that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to oxidants and antioxidants inside and outside of cells. Example products include an anti-microbial toothpaste with anti-plaque properties, an anti-inflammatory skin lotion with antioxidant, antimicrobial, and deodorant properties, and an anti-toxin skin lotion with anti-arsenicosis properties.

US Patent:

20130165515, Jun 27, 2013

Filed:

Dec 3, 2012

Appl. No.:

13/694447

Inventors:

David Michael Ott - Oakland CA, US

International Classification:

C07C 323/59
C07C 319/24

US Classification:

514562, 562557

Abstract:

Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.