David L Payne

US Patent:

6346396, Feb 12, 2002

Filed:

Jan 29, 1999

Appl. No.:

09/240936

Inventors:

Jianzhong Huang - King of Prussia PA 19406-0939
Xinhe Jiang - King of Prussia PA 19406-0939
David Payne - King of Prussia PA 19406-0939
Stephanie Van Horn - King of Prussia PA 19406-0939
Nicola Gail Wallis - King of Prussia PA 19406-0939

International Classification:

C12P 2106

US Classification:

435 691, 435 6, 4353201, 435325, 4352532, 435243, 536 232

Abstract:

The invention provides MurA polypeptides and polynucleotides encoding MurA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurA polypeptides to screen for antibacterial compounds.

US Patent:

6432670, Aug 13, 2002

Filed:

Apr 15, 1999

Appl. No.:

09/292412

Inventors:

David John Payne - Phoenixville PA
Peter Henry Milner - Great Dunmow, GB
Stewart Campbell Pearson - Berwyn PA
John Timothy Lonsdale - Exton PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07H 2104

US Classification:

435 691, 435 711, 435 712, 4352523, 4353201, 4242001, 536 232, 536 234, 536 237

Abstract:

Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.

US Patent:

6682919, Jan 27, 2004

Filed:

Nov 14, 1997

Appl. No.:

08/970647

Inventors:

Christine Debouck - Wayne PA
Daniel Robert Gentry - Pottstown PA
Deborah Dee Jaworski - West Chester PA
John Timothy Londsdale - Exton PA
Jeffrey L Mooney - Limerick PA
David John Payne - Phoenixville PA
Stewart Campbell Pearson - Berwyn PA
Lisa Kathleen Schilling - Newtown PA
Glenn Scott Van Aller - Reading PA
Min Wang - Blue Bell PA
Yi Yi Zhong - Collegeville PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 910

US Classification:

435193, 4353201, 435325, 4352523, 536 232

Abstract:

The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.

US Patent:

6753172, Jun 22, 2004

Filed:

Apr 15, 1999

Appl. No.:

09/292411

Inventors:

David John Payne - Phoenixville PA
Peter Henry Milner - Great Dunmow, GB
Stewart Campbell Pearson - Berwyn PA
John Timothy Lonsdale - Exton PA

Assignee:

Affinium Pharmaceuticals, Inc. - Toronto

International Classification:

C12N 900

US Classification:

435183, 530300, 530324, 530350

Abstract:

Prokayrotic FABI polypeptides and DNA (RNA) encoding such FABI and a procedure for such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FABI for the treatment of infection, such as bacterial infections. Antagonists against such FABI and their use as a therapeutic to treat infections, such asstaphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FABI nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FABI and for detecting the polypeptide in a host.

US Patent:

6821746, Nov 23, 2004

Filed:

Oct 1, 2001

Appl. No.:

09/968129

Inventors:

David John Payne - Collegeville PA
Nicola Gail Wallis - Cambridge, GB
Joshua M. West - Collegeville PA

Assignee:

Affinium Pharmaceuticals, Inc. - Ontario

International Classification:

C12Q 132

US Classification:

435 26, 435 71

Abstract:

The invention provides methods for identifying agonists and antagonists of FabK polypeptides.

US Patent:

6995254, Feb 7, 2006

Filed:

Jan 28, 1997

Appl. No.:

08/790043

Inventors:

David John Payne - Phoenixville PA, US
Peter Henry Milner - Great Dunmow, GB
Stewart Campbell Pearson - Berwyn PA, US
John Timothy Lonsdale - Exton PA, US

Assignee:

Affinium Pharmaceuticals, Inc. - Toronto

International Classification:

C07H 21/00
C12N 15/31
C12N 15/53

US Classification:

536 237, 4352523, 43525411, 4353201, 435325, 435455, 435471, 536 231, 536 232, 536 234

Abstract:

Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such as staphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.

US Patent:

7033795, Apr 25, 2006

Filed:

Nov 26, 2002

Appl. No.:

10/304617

Inventors:

David John Payne - Collegeville PA, US
Nicola Gail Wallis - Cambridge, GB
Joshua M. West - Collegeville PA, US

Assignee:

Affinium Pharmaceuticals, Inc. - Toronto

International Classification:

C07K 14/315
C12N 5/10
C12N 15/11
C12N 15/64
A61K 39/09

US Classification:

435 691, 4352534, 4352523, 435 711, 536 231, 536 232, 536 235, 536 237, 536 243, 536 2432, 530350, 4242441, 4241841

Abstract:

The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing FabK polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.

US Patent:

7048926, May 23, 2006

Filed:

Apr 4, 2003

Appl. No.:

10/407028

Inventors:

Martin Brandt - North Wales PA, US
Paul M. Keller - West Chester PA, US
Arunbhai H. Patel - Colonial Beach VA, US
David J. Payne - Phoenixville PA, US
Shannon L. Reed - Norristown PA, US
Mark A. Seefeld - Collegeville PA, US
David G. Tew - Harlow, GB
Nicola G. Wallis - Wayne PA, US
Joshua M. West - Allentown PA, US

Assignee:

Affinium Pharmaceuticals, Inc. - Toronto

International Classification:

A61K 39/00
A01N 37/18

US Classification:

4241841, 514 2

Abstract:

The invention provides methods for using agonists and antagonists of FabK polypeptides, particularly to modulate the metabolism of bacteria or to treat bacterial infection.