David Everette Pierce

US Patent:

8540942, Sep 24, 2013

Filed:

Jan 13, 2010

Appl. No.:

12/686815

Inventors:

David Kyle Pierce - Elkton MD, US
Mark G. Mortenson - North East MD, US
David A. Bryce - Elkton MD, US

International Classification:

B01J 19/08

US Classification:

422186, 204164, 42218603, 42218604, 205357, 205571

Abstract:

This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e. g. , nanoparticles) are caused to be present (e. g. , created and/or the liquid is predisposed to their presence (e. g. , conditioned)) in a liquid (e. g. , water) by, for example, preferably utilizing at least one adjustable plasma (e. g. , created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s).

US Patent:

8617360, Dec 31, 2013

Filed:

Jul 11, 2008

Appl. No.:

12/668181

Inventors:

David K. Pierce - Elkton MD, US
Mark G. Mortenson - North East MD, US
David A. Bryce - Elkton MD, US

Assignee:

GR Intellectual Reserve, LLC - Havre de Grace MD

International Classification:

H05F 3/00
C25C 1/22
C25C 1/20
H05F 3/06
H05F 3/02
H05F 3/04

US Classification:

204164, 205560, 205565, 205571, 205574, 205602

Abstract:

Methods and devices for the continuous manufacture of nanop∈rticles, microparticles and nanoparticle/liquid solution(s) are disclosed. The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e. g. , nanoparticles) are caused to be present (e. g. , created) in a liquid (e. g. , water) by utilizing at least one adjustable plasma (e. g. , created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s).

US Patent:

20080277272, Nov 13, 2008

Filed:

Jan 3, 2007

Appl. No.:

12/159869

Inventors:

David Kyle Pierce - Elkton MD, US
David A. Bryce - Elkton MD, US
Mark G. Mortenson - North East MD, US

International Classification:

B01J 19/08

US Classification:

204164, 204176

Abstract:

This invention relates generally to novel methods for affecting, controlling, and/or directing various reactions with and in various liquids (such as water) by creating an energy field within and/or juxtaposed to at least one surface of said liquid. An important aspect of the invention involves the creation of a plasma, which plasma is created between at least one electrode located above the surface of the liquid and at least a portion of the surface of the liquid itself, which functions as at least one second electrode. In order to permit at least a portion of the surface of the liquid to function effectively as a second electrode, at least one additional electrically conducting electrode is typically located within (e.g., at least partially submerged within) said liquid. The plasma results in a restructuring of the liquid and/or the presence of at least one active species within said liquid.

US Patent:

20110278178, Nov 17, 2011

Filed:

Jan 13, 2010

Appl. No.:

13/144221

Inventors:

David Kyle Pierce - Elkton MD, US
Mark Gordon Mortenson - North East MD, US
David Andrew Bryce - Elkton MD, US
Adam Robert Dorfman - Baltimore MD, US
Mikhail Merzliakov - Parkville MD, US
Arthur Maxwell Grace - North East MD, US

International Classification:

C25C 7/02
C25C 1/16
C25C 7/06
C25C 1/22

US Classification:

205571, 204242, 205602, 2042751

Abstract:

This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized. The continuous processes cause at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including ions, micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, concentration, zeta potential and certain other novel properties present in a liquid.

US Patent:

20210052638, Feb 25, 2021

Filed:

Oct 9, 2019

Appl. No.:

16/501474

Inventors:

David Kyle Pierce - Elkton MD, US
Mark G. Mortenson - North East MD, US
David A. Bryce - Elkton MD, US

Assignee:

Clene Nanomedicine, Inc. - North East MD

International Classification:

A61K 33/30
B01J 19/08
A61K 9/51
A61K 33/38

Abstract:

This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

US Patent:

20190009342, Jan 10, 2019

Filed:

Jul 16, 2018

Appl. No.:

16/036325

Inventors:

David Kyle Pierce - Elkton MD, US
Mark Gordon Mortenson - North East MD, US
David Andrew Bryce - Elkton MD, US
Adam Robert Dorfman - Baltimore MD, US
Mikhail Merzliakov - Parkville MD, US
Arthur Maxwell Grace - North East MD, US

Assignee:

Clene Nanomedicine, Inc. - North East MD

International Classification:

B22F 9/20
C25C 1/22
B01J 19/08
B82Y 40/00
C25C 1/20

Abstract:

This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized. The continuous processes cause at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including ions, micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, concentration, zeta potential and certain other novel properties present in a liquid.

US Patent:

20160375058, Dec 29, 2016

Filed:

Jun 30, 2016

Appl. No.:

15/199009

Inventors:

David Kyle Pierce - Elkton MD, US
Mark G. Mortenson - North East MD, US
David A. Bryce - Elkton MD, US

Assignee:

GR Intellectual Reserve, LLC - Havre de Grace MD

International Classification:

A61K 33/30
A61K 9/51
B01J 19/08
A61K 33/38

Abstract:

This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

US Patent:

20150167189, Jun 18, 2015

Filed:

Aug 25, 2014

Appl. No.:

14/338868

Inventors:

David Kyle Pierce - Elkton MD, US
Mark Gordon Mortenson - North East MD, US
David Andrew Bryce - Ekden MD, US
Adam Robert Dorfman - Baltimore MD, US
Mikhail Merzliakov - Parkville MD, US
Arthur Maxwell Grace - Baltimore MD, US

Assignee:

GR Intellecturl Reserve, LLC - Havre de Grace MD

International Classification:

C25C 1/22

Abstract:

This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized. The continuous processes cause at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including ions, micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, concentration, zeta potential and certain other novel properties present in a liquid.