David B Reitz

US Patent:

6369220, Apr 9, 2002

Filed:

Oct 2, 2000

Appl. No.:

09/581897

Inventors:

Ching-Cheng Wang - Wildwood MO 63011
David B. Reitz - Chesterfield MO 63017
Victor Snieckus - Queens University Kingston, Ontario, CA
Horng-Chih Huang - Chesterfield MO 63017
Andrew J. Carpenter - Research Triangle Park NC 27709-3398

International Classification:

C07D24502

US Classification:

540473, 549 9, 51421101

Abstract:

A process for preparing enantiomerically enriched tetrahydrobenzothipeine oxides comprises cyclizing an enantiomerically enriched aryl-3-propanalsulfoxide wherein the sulfur atom of the aryl-3-propanalsulfoxide is a chiral center.

US Patent:

6387924, May 14, 2002

Filed:

Apr 9, 2001

Appl. No.:

09/828968

Inventors:

Len F. Lee - St. Charles MO
Shyamal C. Banerjee - Chesterfield MO
Horng-Chih Huang - Chesterfield MO
Jinglin J. Li - Chesterfield MO
Raymond E. Miller - Fairview Heights IL
David B. Reitz - Chesterfield MO
Samuel J. Tremont - St. Louis MO

Assignee:

G.D. Searle Co. - Skokie IL

International Classification:

A61K 3144

US Classification:

514300, 514431, 544122, 549 9

Abstract:

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

US Patent:

6492397, Dec 10, 2002

Filed:

Jul 26, 2000

Appl. No.:

09/616639

Inventors:

David B. Reitz - Chesterfield MO
Robert E. Manning - St. Louis MO

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A01N 4330

US Classification:

514338, 514340, 514341, 5462701, 5462704, 5462711, 5462717, 5462721, 5462724, 5462744

Abstract:

A class of N-arylheteroarylalkyl imidazol-2-one compounds is described for use in treatment of arteriosclerosis. Compounds of particular interest are angiotensin II antagonists of Formula I: wherein Ar is selected from wherein m is one; wherein R is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, 2-ethylbutyl, n-pentyl, neopentyl, phenyl, methylphenyl, difluorophenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, cyclohexanoyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R is hydrido; wherein R is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, propylthio, butylthio, and hydroxyalkyl; wherein each of R , R , R , R , R , R , R and R is hydrido and R may be selected from COOH and tetrazolyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof.

US Patent:

6492413, Dec 10, 2002

Filed:

Mar 20, 2000

Appl. No.:

09/528934

Inventors:

John J. Talley - Brentwood MO
Stephen R Bertenshaw - Brentwood MO
Paul W Collins - Deerfield IL
Thomas D. Penning - Elmhurst IL
David B. Reitz - Chesterfield MO
Roland S Rogers - Richmond Heights MO

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 314025

US Classification:

514427, 548530, 548531, 548542, 548560

Abstract:

A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR ; wherein R is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R and R are independently aryl or heteroaryl; and wherein R and R are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.

US Patent:

6599934, Jul 29, 2003

Filed:

Nov 13, 2000

Appl. No.:

09/711737

Inventors:

John J. Talley - Brentwood MO
Stephen R Bertenshaw - Brentwood MO
Paul W Collins - Deerfield IL
Thomas D. Penning - Elmhurst IL
David B. Reitz - Chesterfield MO
Roland S Rogers - Richmond Heights MO

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

C07D30702

US Classification:

514461, 549497

Abstract:

A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR ; wherein R is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R and R are independently aryl or heteroaryl; and wherein R and R are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.

US Patent:

6624180, Sep 23, 2003

Filed:

Nov 20, 2001

Appl. No.:

09/989634

Inventors:

Michael J. South - St. Louis MO
Brenda Case - St. Louis MO
Danny J. Garland - Ballwin MO
Michael J. Hayes - St. Louis MO
Horng-Chih Huang - Chesterfield MO
Wei Huang - Wildwood MO
Darin E. Jones - Ballwin MO
William L. Neumann - St. Louis MO
John J. Parlow - Arnold MO
David B. Reitz - Chesterfield MO
Melvin L. Rueppel - St. Louis MO
Rondald K. Webber - St. Charles MO

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

C07D21306

US Classification:

514352, 514242, 51425506, 514275, 546309, 544194, 544316, 544407

Abstract:

The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

US Patent:

6630497, Oct 7, 2003

Filed:

Apr 3, 2001

Appl. No.:

09/825029

Inventors:

David B. Reitz - Chesterfield MO
Robert E. Manning - St. Louis MO

Assignee:

G.D. Searle Co - Chicago IL

International Classification:

A61K 314178

US Classification:

514381, 514392, 548252, 5483255

Abstract:

A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula wherein each of R , R and R is independently selected from hydrido, alkyl, alkoxy, cyano, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; alkylcarbonyl and haloalkylcarbonyl; with the proviso that at least one of R , R and R must be a substituent other than hydrido, and with the further proviso that when each of R and R is hydrido, then R cannot be chloro; wherein R is hydrido; wherein R is alkyl; and wherein R is tetrazolyl; or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.

US Patent:

6664255, Dec 16, 2003

Filed:

May 18, 2000

Appl. No.:

09/574752

Inventors:

Michael South - St. Louis MO
John J. Parlow - Arnold MO
Darin E. Jones - Ballwin MO
Brenda Case - St. Louis MO
Tom Dice - St. Charles MO
Richard Lindmark - Kirkwood MO
Michael J. Hayes - St. Louis MO
Melvin L. Rueppel - St. Louis MO
Horng-Chih Huang - Chesterfield MO
Wei Huang - Wildwood MO
Scott A. Long - Ballwin MO
Matthew Mahoney - St. Peters MO
William L. Neumann - St. Louis MO
David Reitz - Chesterfield MO
John I. Trujillo - Creve Coeur MO
Ching-Cheng Wang - Wildwood MO
Rhonda Wood - Maryland Heights MO
Qingping Zeng - Ballwin MO
Rick Fenton - Collinsville IL
Gary W. Franklin - Godfrey IL
Carrie Kusturin - Edwardsville IL

Assignee:

Pharmacia Corporation - Chicago IL

International Classification:

C07D24120

US Classification:

5142358, 544405, 544237, 544295, 544120, 51425505, 514248

Abstract:

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

Address:

14814 Pleasant Rdg Ct, Chesterfield, MO 63017

Phone:

(636)5375580

VIN:

4T1BK3DB6BU404590

Make:

TOYOTA

Model:

AVALON

Year:

2011