David B Root

US Patent:

6350618, Feb 26, 2002

Filed:

Apr 27, 1999

Appl. No.:

09/300121

Inventors:

Nicholas F. Borrelli - Elmira NY
Alain R. E. Carre - Le Chatelet-en-Brie, FR
Thierry L. A. Dannoux - Avon, FR
Bernard Eid - Corning NY
David Root - Lexington MA
Raja Rao Wusirika - Painted Post NY

Assignee:

Corning Incorporated - Corning NY

International Classification:

G01N 100

US Classification:

436174, 422100, 7386331, 73864, 436180

Abstract:

Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate.

US Patent:

6514402, Feb 4, 2003

Filed:

Dec 6, 2000

Appl. No.:

09/731423

Inventors:

Narayan V. Iyer - Horseheads NY
William J. Lacey - North Andover MA
David M. Root - Westford MA

Assignee:

Corning Incorporated - Corning NY

International Classification:

G01N 2731

US Classification:

205793, 205789, 205778, 204416, 204431, 20440306

Abstract:

The present invention includes a method and sensor that is easy to assemble and can operate to effectively detect an air borne or exogenously introduced analyte. In one embodiment, the assembled sensor includes a top cap capable of receiving a first electrolyte and a bottom cap capable of receiving a second electrolyte. The assembled sensor also includes a flexible boot that holds together the top cap, the bottom cap and a membrane. The membrane is located between the first electrolyte and the second electrolyte and enables an electrical device to detect an analyte (e. g. , hazardous chemical) which originally entered the sensor through a passage in the top cap and interacted with the membrane.

US Patent:

6596237, Jul 22, 2003

Filed:

Apr 26, 1999

Appl. No.:

09/299766

Inventors:

Nicholas F. Borrelli - Elmira NY 14905
Alain R. E. Carre - 77820 Le Chatelet-En-Brie, FR
Thierry L. A. Dannoux - Avon, FR
Bernard Eid - Corning NY 14830
David Root - Lexington MA 02173
Raja Rao Wusirika - Painted Post NY 14870

International Classification:

B01L 302

US Classification:

422100, 436180, 7386331, 73864, 101327, 101335, 101368

Abstract:

Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate.

US Patent:

6762061, Jul 13, 2004

Filed:

Mar 15, 2000

Appl. No.:

09/525919

Inventors:

Nicholas F. Borrelli - Elmira NY
Alain R. E. Carre - Le Chatelet-en-Brie, FR
Thierry L. A. Dannoux - Avon, FR
Bernard Eid - Corning NY
David Root - Lexington MA
Raja Rao Wusirika - Painted Post NY

Assignee:

Corning Incorporated - Corning NY

International Classification:

G01N 100

US Classification:

436180, 436174, 422100, 422 99, 101 9337, 101368, 101327, 7386331, 7386401

Abstract:

Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate.

US Patent:

6884626, Apr 26, 2005

Filed:

Mar 15, 2000

Appl. No.:

09/525920

Inventors:

Nicholas F. Borrelli - Elmira NY, US
Alain R. E. Carre - Le Chatelet-en-Brie, FR
Thierry L. A. Dannoux - Avon, FR
Bernard Eid - Corning NY, US
David Root - Lexington MA, US
Raja Rao Wusirika - Painted Post NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

G01N001/16
G01N001/26
G01N001/00
G01N001/10
B01L003/02

US Classification:

436180, 436174, 422100, 422 99, 422102, 7386331, 73864

Abstract:

Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate.

US Patent:

7332328, Feb 19, 2008

Filed:

Sep 6, 2002

Appl. No.:

10/236120

Inventors:

Brian L. Webb - Painted Post NY, US
Jinlin Peng - Painted Post NY, US
Michael D. Brady - Painted Post NY, US
Mircea Despa - Horseheads NY, US
Keith A. Horn - Corning NY, US
Joydeep Lahiri - Painted Post NY, US
David M. Root - Westford MA, US
James B. Stamatoff - Painted Post NY, US
Po Ki Yuen - Corning NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

C12M 1/34

US Classification:

4352872, 4352883

Abstract:

A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

US Patent:

20080103059, May 1, 2008

Filed:

Dec 13, 2007

Appl. No.:

12/001850

Inventors:

Brian Webb - Painted Post NY, US
Jinlin Peng - Painted Post NY, US
Michael Brady - Painted Post NY, US
Mircea Despa - Horseheads NY, US
Keith Horn - Corning NY, US
Joydeep Lahiri - Painted Post NY, US
David Root - Westford MA, US
James Stamatoff - Painted Post NY, US

International Classification:

C40B 30/04

US Classification:

506009000

Abstract:

A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

US Patent:

20090186776, Jul 23, 2009

Filed:

Jun 12, 2008

Appl. No.:

12/137918

Inventors:

Brian L. Webb - Painted Post NY, US
Jinlin Peng - Painted Post NY, US
Michael D. Brady - Painted Post NY, US
Mircea Despa - Horseheads NY, US
Keith A. Horn - Corning NY, US
Joydeep Lahiri - Painted Post NY, US
David M. Root - Westford MA, US
James B. Stamatoff - Painted Post NY, US
Po Ki Yuen - Corning NY, US

International Classification:

C40B 30/10
C40B 60/12

US Classification:

506 12, 506 39

Abstract:

A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.