David L Roth

US Patent:

7604995, Oct 20, 2009

Filed:

Jul 9, 2004

Appl. No.:

10/887593

Inventors:

David B. Roth - New York NY, US
Gregory S. Lee - New York NY, US

Assignee:

New York University - New York NY

International Classification:

C12N 15/87
C12N 15/00
C12N 15/64
C12P 19/34

US Classification:

435463, 435455, 435 914, 435 911

Abstract:

A method of stimulating homologous recombination by creating at least one nick in a targeted polynucleotide sequence. Wherein nonhomologous recombination is suppressed resulting in increasing the ratio of targeted to nontargeted events. A method of increasing double strand break-initiated gene targeting by inducing a nick in a targeted polynucleotide sequence, wherein overall recombination levels are increased. A method of increasing homologous recombination employing a recombinase that releases the ends in living cells by stimulating homolgous recombination to higher levels than those attainable with standard nucleases. A composition for stimulating homologous recombination including a nicking mechanism for creating nicks in a polynucleotide, wherein the nicking mechanism stimulates homologous recombination. A composition for stimulating homologous recombination including a nicking endonucleases. Various kits for stimulating homologous recombination.

US Patent:

20050154742, Jul 14, 2005

Filed:

Nov 24, 2004

Appl. No.:

10/996792

Inventors:

Aviv Roth - Brooklyn NY, US
David Roth - New York NY, US

International Classification:

G06F007/00

US Classification:

707100000

Abstract:

A business software application generation system and method are described.

US Patent:

20120174241, Jul 5, 2012

Filed:

Apr 22, 2011

Appl. No.:

13/066750

Inventors:

Ludovic Deriano - New York NY, US
David B. Roth - New York NY, US

International Classification:

A01K 67/027
C40B 30/04
G01N 21/64
G01N 33/53
C12N 5/10

US Classification:

800 10, 435 723, 435354, 435 611, 506 9

Abstract:

The invention provides mutant or transgenic animals and cells derived from the mutant or transgenic animals, and particularly a transgenic mouse, that is useful, among other things, for the study, prognosis and diagnosis of hematological malignancies, including T-cell acute lymphoblastic leukemia (T-ALL). Methods are provided for using the mouse model or mutant animal cells to assist in the discovery and identification of genes that may promote lymphomagenesis, to prognose and diagnose disease, and to screen for potential therapeutic agents or drugs.

US Patent:

46069771, Aug 19, 1986

Filed:

Oct 22, 1984

Appl. No.:

6/663615

Inventors:

James Dickson - Stirling NJ
Louis F. Nienart - Bloomsbury NJ
David W. Roth - Convent Station NJ

Assignee:

Allied Corporation - Morris Township, Morris County NJ

International Classification:

B22F 100
B32B 1500
B32B 1502
B32B 1504

US Classification:

428553

Abstract:

The present invention is for a flat B containing amorphous powder based in Fe, Ni, Co or a combination thereof; a coating resulting from deposition of the powder; and a method for depositing the powder. The composition of the powder and the resulting coating consists essentially of the formulation: (Fe,Ni,Co). sub. bal Cr. sub. 0-20 (Mn,Mo,W). sub. 0-35 (B,Si,C). sub. 5-25 (Al,Ti). sub. 0-10 where the subscripts are in atomic percent and with the proviso that 4. ltoreq. B. ltoreq. 15, and that the balance will exceed 50%.

US Patent:

45030855, Mar 5, 1985

Filed:

Feb 7, 1983

Appl. No.:

6/464180

Inventors:

James Dickson - Stirling NJ
Louis F. Nienart - Bloomsbury NJ
David W. Roth - Convent Station NJ

Assignee:

Allied Corporation - Morris Township, Morris County NJ

International Classification:

B05D 110
B22F 906
C22C 1908
C22C 3302

US Classification:

427 34

Abstract:

The present invention is for a flat B containing amorphous powder based in Fe, Ni, Co or a combination thereof; a coating resulting from deposition of the powder; and a method for depositing the powder. The composition of the powder and the resulting coating consists essentially of the formulation: (Fe,Ni,Co). sub. bal Cr. sub. 0-20 (Mn,Mo,W). sub. 0-35 (B,Si,C). sub. 5-25 (Al,Ti). sub. 0-10 where the subscripts are in atomic percent and with the proviso that 4. ltoreq. B. ltoreq. 15, and that the balance will exceed 50%.