David P Rounbehler

US Patent:

7025869, Apr 11, 2006

Filed:

Aug 28, 2002

Appl. No.:

10/229026

Inventors:

David H. Fine - Lincoln MA, US
Stephen J. MacDonald - Salem NH, US
David Rounbehler - West Harwich MA, US
David Wheeler - Lunenburg MA, US
Jonathan L. Rolfe - N. Easton MA, US
George Jarvis - Arlington MA, US

Assignee:

CyTerra Corporation - Waltham MA

International Classification:

C25B 1/22
A61M 16/00
A01D 59/00

US Classification:

205553, 12820418, 12820421, 424718

Abstract:

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.

US Patent:

7040313, May 9, 2006

Filed:

Aug 28, 2002

Appl. No.:

10/228958

Inventors:

David H. Fine - Lincoln MA, US
Stephen J. MacDonald - Salem NH, US
David Rounbehler - West Harwich MA, US
David Wheeler - Lunenburg MA, US
Jonathan L. Rolfe - N. Easton MA, US
George Jarvis - Arlington MA, US

Assignee:

CyTerra Corporation - Waltham MA

International Classification:

A61M 16/00

US Classification:

12820312

Abstract:

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.

US Patent:

7560076, Jul 14, 2009

Filed:

Aug 18, 2005

Appl. No.:

11/206305

Inventors:

David R. Rounbehler - Las Cruces NM, US
David H. Fine - Cocoa Beach FL, US

Assignee:

GENO LLC - Lincoln MA

International Classification:

A62B 7/08
A61M 16/00

US Classification:

422120, 422122, 95102, 95105, 95120, 12820014, 12820312, 96154, 96153

Abstract:

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.

US Patent:

7618594, Nov 17, 2009

Filed:

Mar 7, 2006

Appl. No.:

11/276610

Inventors:

David R. Rounbehler - Las Cruces NM, US
David H. Fine - Cocoa Beach FL, US

Assignee:

GeNO LLC - Cocoa FL

International Classification:

A62B 7/08
A61M 16/00

US Classification:

422120, 422122, 95102, 95105, 95120, 96154, 96153, 12820014, 12820312

Abstract:

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

US Patent:

7914743, Mar 29, 2011

Filed:

Jan 28, 2009

Appl. No.:

12/361274

Inventors:

David Fine - Cocoa FL, US
Gregory Vasquez - Cocoa FL, US
David P. Rounbehler - Las Cruces NM, US

Assignee:

Geno LLC - Cocoa FL

International Classification:

A62B 7/08

US Classification:

422120, 422129, 422177, 95128, 95129, 424718, 12820312, 12820527, 73 232, 423235, 4232391, 423400, 423405

Abstract:

Various systems, devices, NOabsorbents, NOscavengers and NOrecuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

US Patent:

7947227, May 24, 2011

Filed:

Mar 21, 2008

Appl. No.:

12/076723

Inventors:

David H. Fine - Cocoa Beach FL, US
David P. Rounbehler - Las Cruces NM, US
Greg Vasquez - Melbourne FL, US

Assignee:

Geno LLC - Cocoa FL

International Classification:

A62B 7/08
A61M 15/00

US Classification:

422120, 422122, 95102, 95120, 12820312, 12820314, 12820424, 12820421

Abstract:

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

US Patent:

8057742, Nov 15, 2011

Filed:

Nov 17, 2009

Appl. No.:

12/619959

Inventors:

David R. Rounbehler - Las Cruces NM, US
David H. Fine - Cocoa Beach FL, US

Assignee:

Geno LLC - Cocoa FL

International Classification:

A61M 15/00
A62B 7/08

US Classification:

422120, 422122, 12820024

Abstract:

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

US Patent:

8066904, Nov 29, 2011

Filed:

Aug 28, 2002

Appl. No.:

10/228956

Inventors:

David H. Fine - Lincoln MA, US
Stephen J. MacDonald - Salem NH, US
David Rounbehler - West Harwich MA, US
David Wheeler - Lunenburg MA, US
Jonathan L. Rolfe - N. Easton MA, US
George Jarvis - Arlington MA, US

Assignee:

Geno LLC - Cocoa FL

International Classification:

A61K 33/00
A61K 33/24
A61K 33/30
A61K 33/34
A61K 9/00
A61K 9/20
A61M 16/10
C09K 3/00

US Classification:

25218644, 25218234, 424718, 424485, 424486, 424487, 424488, 424499

Abstract:

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.