David R Schubert

US Patent:

6472436, Oct 29, 2002

Filed:

Jul 17, 2000

Appl. No.:

09/617147

Inventors:

David R. Schubert - La Jolla CA
Yuanbin Liu - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 3105

US Classification:

514731, 514453, 514456

Abstract:

In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing amyloid protein production in cells and methods of inhibiting cell death. Invention methods can be used to prevent and treat a diverse class of disease conditions, known as amyloidoses, which are all related to the occurrence of amyloid protein deposits. Invention methods further provide methods of identifying compounds that can block amyloid toxicity or block the amyloid protein induced inhibition of MMT reduction.

US Patent:

6919036, Jul 19, 2005

Filed:

Jan 18, 2001

Appl. No.:

10/181628

Inventors:

David M. Schubert - Los Angeles CA, US

Assignee:

U.S. Borax Inc. - Valencia CA

International Classification:

C01B035/18
C07F005/02
C09K021/00
A01N055/08

US Classification:

252601, 25238941, 423277, 501 964, 514 64, 564 8

Abstract:

A family of borate compounds containing an isolated (finite) nonaborate anion with the structural formula [BO(OH)]. Preferred amine nonaborate compounds have a resolved oxide formula of AO. 3BO. 2HO, where A is the monovalent cation of an amine salt, such as guanidinium and imidazolium. Also provided is a method for preparing these compounds by crystallization from an aqueous solution under mild conditions without the formation of significant amounts of by-products. These compounds have potential application as precursors for the production of advanced boron nitride ceramic materials, and as flame retardants, corrosion inhibitors, and biocides.

US Patent:

7053116, May 30, 2006

Filed:

Oct 11, 2002

Appl. No.:

10/269477

Inventors:

David R. Schubert - La Jolla CA, US
Yuanbin Liu - San Diego CA, US

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 31/335

US Classification:

514452, 514456, 514457, 514866

Abstract:

In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing amyloid protein production in cells and methods of inhibiting cell death. Invention methods can be used to prevent and treat a diverse class of disease conditions, known as amyloidoses, which are all related to the occurrence of amyloid protein deposits. Invention methods further provide methods of identifying compounds that can block amyloid toxicity or block the amyloid protein induced inhibition of MMT reduction.

US Patent:

7531669, May 12, 2009

Filed:

Dec 30, 2005

Appl. No.:

11/323987

Inventors:

David R. Schubert - La Jolla CA, US
Yuanbin Liu - San Diego CA, US
Thomas Baiga - San Marcos CA, US

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C07D 231/10
C07D 231/12

US Classification:

5483751, 5483761, 5483771

Abstract:

In accordance with the present invention, there are provided novel compounds that protect neurons and/or promote neuroregeneration and/or promote memory formation. Such compounds are useful for treatment of a variety of neural disorders and conditions. In another aspect of the present invention, there are also provided formulations containing one or more of the above-described compounds, optionally further containing additional neurologically active compound(s) and/or adjuvants to facilitate delivery thereof across the blood/brain barrier. In still another aspect of the present invention, there are further provided methods for treating a wide variety of neurological indications, e. g. , acute neural injuries, chronic injuries, promoting memory formation, and the like.

US Patent:

8466195, Jun 18, 2013

Filed:

Mar 15, 2010

Appl. No.:

13/255192

Inventors:

Pamela A. Maher - La Jolla CA, US
David R. Schubert - La Jolla CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 31/353

US Classification:

514456

Abstract:

Disclosed herein, inter alia, are methods and compositions for treating a complication of diabetes or a vascular disease using a 5-desoxy-flavone and/or 5-desoxy-flavonol.

US Patent:

20030077740, Apr 24, 2003

Filed:

Sep 3, 2002

Appl. No.:

10/234961

Inventors:

David Schubert - La Jolla CA, US
Atsushi Kashiwa - Yokohama, JP
Hideo Kimura - Tokyo, JP

International Classification:

C12P021/02
C12N005/06
C07H021/04
C12N009/64

US Classification:

435/069100, 435/320100, 435/226000, 435/325000, 536/023200

Abstract:

The invention provides Presenilin/Crk binding polypeptides characterized by interacting with Presenilin polypeptides, modulating intracellular calcium mobilization, and redistributing from cytoplasm to membrane in the presence of a Presenilin polypeptide. The Presenilin/Crk binding polypeptides are further characterized by interacting with a Crk polypeptide and by containing at least one SH3 domain. Also provided are isolated nucleic acids encoding Presenilin/Crk binding polypeptides, antibodies that bind to Presenilin/Crk binding polypeptides, expression vectors containing Presenilin/Crk binding polynucleotides and host cells transformed by Presenilin/Crk binding polynucleotides. The invention provides a method for identifying a compound that modulates intracellular calcium mobilization and/or modulates Presenilin/Crk binding protein levels or activity. The invention includes a method of treating a disorder associated with Presenilin/Crk binding protein. Also provided is a method of diagnosis of a subject having or at risk of having a disorder of the nervous system such as Alzheimer's disease.

US Patent:

20100305181, Dec 2, 2010

Filed:

Oct 14, 2008

Appl. No.:

12/682767

Inventors:

David R. Schubert - La Jolla CA, US

International Classification:

A61K 31/415
C07C 241/00
A61K 31/16
C07D 231/12
A61P 25/00

US Classification:

514406, 564151, 514614, 5483771

Abstract:

In accordance with the present invention, there are provided novel compounds that have a variety of properties, i.e., antioxidant, anti-inflammatory, antiviral, antibacterial, and antifungal properties. Invention compounds, therefore, have the ability to impart a variety of beneficial physiological effects, e.g., to protect neurons and/or to promote neuroregeneration and/or to promote memory formation and/or to act as protein phosphatase or kinase inhibitors and/or to act as lipoxygenase inhibitors. Such compounds are useful for treatment of a variety of indications, including neurodegenerative diseases and conditions, diabetes, ischemia associated with heart disease, and memory deficit. In another aspect of the present invention, there are also provided formulations containing one or more of the above-described compounds, optionally further containing additional neurologically active compound(s) and/or adjuvants to facilitate delivery thereof across the blood/brain barrier. In still another aspect of the present invention, there are further provided methods for treating a wide variety of neurological indications, e.g., acute neural injuries, chronic injuries, promoting memory formation, and the like.

US Patent:

56120940, Mar 18, 1997

Filed:

Oct 18, 1995

Appl. No.:

8/544903

Inventors:

David M. Schubert - Los Angeles CA
Mark J. Manning - Los Angeles CA

Assignee:

U.S. Borax Inc. - Valencia CA

International Classification:

A01N 300
A01N 5914

US Classification:

427397

Abstract:

Lumber, plywood and other wood products are preserved from attack by fungi, termites and wood-destroying insects as well as fire and flame by treatment with a novel zirconium borate-containing preservative composition. The preservative can be formed by combination of a source of boron such as boric acid and the water-soluble salts thereof with a water-soluble zirconium salt. The ZrO. sub. 2 :B. sub. 2 O. sub. 3 weight ratio in the preservative composition is in the range of from about 0. 75:1 to about 10:1.

Address:

2405 Ellentown Rd, La Jolla, CA 92037

Phone:

(858)4521649

VIN:

JTDKN3DP6C3009338

Make:

TOYOTA

Model:

PRIUS PLUG-IN HYBRID

Year:

2012