David K Shum

US Patent:

20100210649, Aug 19, 2010

Filed:

Dec 21, 2007

Appl. No.:

12/520434

Inventors:

Hakim Djaballah - Scarsdale NY, US
Harold E. Varmus - New York NY, US
David Shum - New York NY, US
Romel Somwar - New York NY, US
Alexander Chucholowski - San Diego CA, US
Mohan Santhanam Thiruvazhi - San Diego CA, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 31/5375
C07D 237/04
A61K 31/50
C07D 417/10
A61K 31/501
C07D 487/04
A61K 31/5025
C07D 237/10
A61K 31/53
C07D 417/14
C07D 413/04
A61P 35/00

US Classification:

5142365, 544241, 514247, 544238, 51425206, 544240, 544236, 514248, 544209, 514245, 544235, 544114, 51425203

Abstract:

The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

US Patent:

20130131062, May 23, 2013

Filed:

Dec 21, 2007

Appl. No.:

12/520256

Inventors:

Hakim Djaballah - Scarsdale NY, US
Harold E. Varmus - New York NY, US
David Shum - Forest Hills NY, US
Romel Somwar - New York NY, US
Alexander Chucholowski - San Diego CA, US
Mohan Santhanam Thiruvazhi - San Diego CA, US

International Classification:

C07D 237/04
C07D 401/04
C07D 405/14
C07D 403/04
C07D 405/10
C07D 471/04
C07D 401/14
C07D 413/04
C07D 495/04
C07D 409/14
C07D 417/10
C07D 405/12

US Classification:

5142365, 544241, 514247, 544238, 51425206, 51425203, 544240, 51425201, 51425205, 544236, 514248, 544209, 514245, 544114, 544235, 544224, 51425202

Abstract:

The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.