David Joseph Speca

US Patent:

20030105285, Jun 5, 2003

Filed:

May 17, 2002

Appl. No.:

10/151208

Inventors:

John Ngai - Berkeley CA, US
David Speca - Berkeley CA, US
David Lin - Berkeley CA, US
Ehud Isacoff - Berkeley CA, US
Andrew Dittman - Berkeley CA, US
Jinhong Fan - Berkeley CA, US

International Classification:

C07K014/705
C07H021/04
C12P021/02
C12N005/06

US Classification:

530/350000, 536/023500, 435/069100, 435/320100, 435/325000

Abstract:

The invention provides methods and compositions relating to odorant receptors, including a general expression cloning methodology which is useful for identifying novel G protein-coupled receptors and a novel family of odorant receptors and related nucleic acids, ligands, agonists and antagonists. These compositions provide a wide variety of applications such as screening for related receptors, and by modulating the function of the disclosed receptors by modulating their expression or contacting them with agonists, antagonist or ligands modulating reproductive/sexual and non-sexual social behaviors mediated via the olfactory system, reproductive physiologies and olfactory system regulated feeding behaviors, migratory behaviors and events such as conception, implantation, estrous and menstruation.

US Patent:

6410249, Jun 25, 2002

Filed:

Jul 19, 2000

Appl. No.:

09/619353

Inventors:

John Ngai - Berkeley CA
David J. Speca - Berkeley CA
David M. Lin - Berkeley CA
Ehud Y. Isacoff - Berkeley CA
Andrew H. Dittman - Berkeley CA
Jinhong Fan - Berkeley CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33566

US Classification:

435 721, 435 6, 435 72, 435 691, 4352523, 436501, 536 235, 530350

Abstract:

The invention provides methods and compositions relating to odorant receptors, including a general expression cloning methodology which is useful for identifying novel G protein-coupled receptors and a novel family of odorant receptors and related nucleic acids, ligands, agonists and antagonists. These compositions provide a wide variety of applications such as screening for related receptors, and by modulating the function of the disclosed receptors by modulating their expression or contacting them with agonists, antagonist or ligands modulating reproductive/sexual and non-sexual social behaviors mediated via the olfactory system, reproductive physiologies and olfactory system regulated feeding behaviors, migratory behaviors and events such as conception, implantation, estrous and menstruation.