David J Strachan

US Patent:

6690464, Feb 10, 2004

Filed:

Feb 18, 2000

Appl. No.:

09/507293

Inventors:

E. Neil Lewis - Brookville MD
David J. Strachan - Baltimore MD
Linda H. Kidder - Wolney MD

Assignee:

Spectral Dimensions, Inc. - Olney MD
The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

G01J 328

US Classification:

356326, 356416, 25033902

Abstract:

Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

US Patent:

7148963, Dec 12, 2006

Filed:

Dec 9, 2004

Appl. No.:

11/007969

Inventors:

Harry Owen - Ann Arbor MI, US
David J. Strachan - Timonium MD, US
Joseph B. Slater - Dexter MI, US
James M. Tedesco - Livonia MI, US

Assignee:

Kaiser Optical Systems - Ann Arbor MI

International Classification:

G01N 21/64

US Classification:

356301, 356317

Abstract:

A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to traditional confocal Raman probes. The inventive probe collects spectra from an area or 1 mm or greater, preferably 3–12 mm or more, compared to current instruments which utilize spot sizes on the order of 2–60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.

US Patent:

7399968, Jul 15, 2008

Filed:

Feb 10, 2004

Appl. No.:

10/776029

Inventors:

E. Neil Lewis - Brookville MD, US
David J. Strachan - Baltimore MD, US
Linda H. Kidder - Wolney MD, US

Assignee:

Malvern Instruments Incorporated - Southborough MA

International Classification:

G01J 3/28

US Classification:

25033912, 250226, 356326

Abstract:

Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

US Patent:

20090294673, Dec 3, 2009

Filed:

Jul 15, 2008

Appl. No.:

12/218504

Inventors:

E. Neil Lewis - Brookville MD, US
David J. Strachan - Baltimore MD, US
Linda H. Kidder - Wolney MD, US

International Classification:

G01J 5/02

US Classification:

25033912

Abstract:

Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.