David Ryan Sullivan

US Patent:

20050042698, Feb 24, 2005

Filed:

Mar 28, 2003

Appl. No.:

10/502834

Inventors:

Plamen Demirev - Ellicott City MD, US
Andrew Feldman - Columbia MD, US
Nirbhay Kumar - Bethesda MD, US
Peter Scholl - Baltimore MD, US
David Sullivan - Baltimore MD, US

International Classification:

G01N033/53
G01N033/569

US Classification:

435007220

Abstract:

Mass spectrometric techniques are provided for detecting the presence of parasites that accumulate unbound heme in red blood cells (including malaria parasites), based on the discovery that unbound heme can be detected and quantified using mass spectrometry. In one aspect of the invention, the method includes the steps of: obtaining a blood sample from the animal; preparing a test sample on a support from the blood sample, and inserting the support into a mass spectrometer for analysis. Next one obtains a mass spectrum of the test sample and determines whether the mass spectrum contains a mass/charge signature of unbound heme. If it is determined that the mass spectrum of the test sample shows the mass/charge signature of unbound heme, the animal is diagnosed as infected with malaria parasites.

US Patent:

20080193499, Aug 14, 2008

Filed:

Jun 27, 2005

Appl. No.:

11/630596

Inventors:

Jun Liu - Clarksville MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61F 2/00
A61K 31/513
A61K 31/343
A61K 31/58
A61K 31/4196
A61K 31/506
A61K 9/00
A61K 38/50
A61K 31/496

US Classification:

424423, 514274, 514470, 514176, 424 946, 51425407, 424484, 514383, 514256

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

US Patent:

20100330148, Dec 30, 2010

Filed:

Mar 20, 2007

Appl. No.:

12/225391

Inventors:

Jun O. Liu - Clarksville MD, US
Curtis Robert Chong - Honolulu HI, US
David J. Sullivan - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61M 31/00
A61K 38/50
A61K 31/7052
A61K 31/4174
A61K 31/496
A61K 31/4196
A61K 31/506
A61K 31/7072
A61K 31/58
A61P 35/00
A61P 17/00
A61P 7/10
A61P 19/02
A61P 29/00
A61P 3/00

US Classification:

424427, 424 946, 514 43, 514396, 514399, 51425407, 514383, 514256, 514 50, 514176

Abstract:

Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject.

US Patent:

20210385190, Dec 9, 2021

Filed:

Jun 5, 2020

Appl. No.:

16/894076

Inventors:

- Mayfield Heights OH, US
Kevin Colloton - Milwaukee WI, US
Joseph P. Izzo - Milwaukee WI, US
Michael A Bush - Mayfield Heights OH, US
David P Sullivan - Mayfield Heights OH, US
Steven Terry Seidlitz - Milwaukee WI, US

International Classification:

H04L 29/06
G05B 19/418

Abstract:

An industrial safety architecture integrates employee identity and enterprise-level security policy into plant-floor functional safety systems, allowing control and safety systems on the plant floor to regulate safe interactions with hazardous controlled machinery based on user identity or role. The architecture leverages existing employee identity and security policy data maintained on the corporate level of an industrial enterprise to manage identity- and/or role-based control and safety on the plant level. Safety authority systems at both the corporate level and the plant level of the industrial enterprise obtain employee and security policy data from corporate-level systems and provides this data in as SIL-rated manner to industrial control and safety systems on the plant floor, where the identity and security policy information is used by functional safety systems to control access to industrial systems as a function of user identity, role, certifications, or other qualifications.