David B Sykes

US Patent:

6884589, Apr 26, 2005

Filed:

Nov 30, 2001

Appl. No.:

10/432057

Inventors:

Mark P. Kamps - Carlsbad CA, US
David B. Sykes - La Jolla CA, US

Assignee:

Regents of the University of California - Oakland CA

International Classification:

C12Q001/68

US Classification:

435 6, 435325, 530350, 536 234

Abstract:

The invention is a genetic construct comprising the coding sequence for a hormone dependent E2a-Pbx1 protein. The invention is the use of the construct to generate hematopoietic cell lines arrested in differentiation upon exposure to the appropriate hormone. Upon removal of the hormone, cells undergo normal, synchronous differentiation providing a system for the study of normal differentiation. Expression of a number of oncogenes in the cells maintains the cells in an undifferentiated state, providing a model for the study the mechanisms of leukemia, and for the testing of pharmacological agents for the treatment and amelioration of the disease.

US Patent:

20020137199, Sep 26, 2002

Filed:

Oct 22, 2001

Appl. No.:

10/011237

Inventors:

Michael Jobin - Boston MA, US
Andrew Muir - Cohasset MA, US
David Sykes - Cambridge MA, US
James Woodward - Milton MA, US

International Classification:

C12M001/34

US Classification:

435/287200

Abstract:

Disclosed are devices and methods for the storage, shipment, moving and/or transferring, mixing, reacting, isolation, conditioning, lyophilization, stabilization, metering, dispensing, detecting, manipulation and management of materials, particularly solids, powders and liquids. Each such device or method provides a means of storing one or more quantities of one or more materials in one or more reservoirs, optionally protecting said quantities from air, moisture or light. Optionally, multiple such reservoirs may be placed or arranged in ensembles such as in arrays or other physical patterns, optionally providing for the simultaneous, parallel or rapid access to more than one such reservoir at once. Devices and methods of the invention may also be configured to deliver material from a reservoir in such manner that a defined or desired quantity of material is dispensed from the reservoir or that such dispensing is performed at a defined or desired rate or that the material is dispensed until one or more criteria are met for such dispensing to cease.

US Patent:

20090068157, Mar 12, 2009

Filed:

Dec 9, 2005

Appl. No.:

11/792988

Inventors:

Mark Kamps - Carlsbad CA, US
David Sykes - Boston MA, US

International Classification:

A61K 35/12
C12N 5/06
C12N 15/87
C12N 5/08
C12Q 1/68
A01K 67/027
A61P 29/00
C12Q 1/02
C12N 15/11
C12N 15/00
C07K 14/00

US Classification:

424 9321, 435377, 435455, 435456, 435366, 435352, 435354, 435 6, 800 3, 435 29, 536 234, 4353201, 530350

Abstract:

A method to generate unlimited numbers of macrophage/dendritic cells or neutrophils from mice, using conditional Hox oncoproteins is disclosed. The invention further includes the establishment of a system to investigate immune responses to microorganisms or diseases involving chronic inflammation.

US Patent:

D3740641, Sep 24, 1996

Filed:

Sep 14, 1995

Appl. No.:

D/044010

Inventors:

Diane M. Brancazio - Cambridge MA
Susannah E. Gardner - Brookline MA
Matthew D. Hern - Boston MA
Francis M. Labrano - Narragansett RI
David A. Snow - Barrington RI
David M. Sykes - Cambridge MA

Assignee:

Fountainhead Technologies - Providence RI

US Classification:

D23209

US Patent:

D3727602, Aug 13, 1996

Filed:

Sep 14, 1995

Appl. No.:

D/044002

Inventors:

Diane M. Brancazio - Cambridge MA
Susannah E. Gardner - Brookline MA
Matthew D. Hern - Boston MA
Francis M. Lubrano - Narragansett RI
David A. Snow - Barrington RI
David M. Sykes - Cambridge MA

Assignee:

Fountainhead Technologies - Providence RI

US Classification:

D23209

US Patent:

D3740633, Sep 24, 1996

Filed:

Apr 25, 1995

Appl. No.:

D/037955

Inventors:

Diane M. Brancazio - Cambridge MA
Susannah E. Gardner - Brookline MA
Matthew D. Hern - Boston MA
Francis M. Lubrano - Narragansett RI
David A. Snow - Barrington RI
David M. Sykes - Cambridge MA

Assignee:

Fountainhead Technologies - Providence RI

US Classification:

D23209

US Patent:

56608020, Aug 26, 1997

Filed:

May 11, 1995

Appl. No.:

8/439214

Inventors:

David D. Archer - Wakefield RI
Diane M. Brancazio - Cambridge MA
Susannah E. Gardner - Brookline MA
Charles F. Heinig - Providence RI
Matthew D. Hern - Boston MA
Francis M. Lubrano - Narragansett RI
David A. Snow - Barrington RI
David M. Sykes - Cambridge MA

Assignee:

Fountainhead Technologies, Inc. - Providence RI

International Classification:

B01D 1102

US Classification:

422261

Abstract:

A water purifier for killing bacteria in water located in a confined area includes a water inlet, a water outlet, and a purification unit that kills the bacteria in the water. A first fluid path is located between the water inlet and the water outlet so that water flowing along the first fluid path flows from the water inlet to the water outlet without passing through the purification unit, and includes a constricted region that has a cross sectional area that is smaller than a cross sectional area of the water inlet. A second fluid path is located between the water inlet and the water outlet, and includes the purification unit, so that water flowing along the second fluid path flows through the purification unit as the water flows from the water inlet to the water outlet. A self-adjusting flow regulator is positioned in the constricted region to automatically modify the cross sectional area of the constricted region to maintain a rate of flow along the second fluid path within a predetermined range as a combined rate of flow along the first and second fluid paths varies.

US Patent:

20220249534, Aug 11, 2022

Filed:

Feb 8, 2022

Appl. No.:

17/650298

Inventors:

- Cambridge MA, US
- Boston MA, US
Frances Flewelling Diehl - Baltimore MD, US
David B. Sykes - Cambridge MA, US

International Classification:

A61K 31/7076
A61K 31/505
A61P 35/00

Abstract:

The present disclosure provides methods for inhibiting cell proliferation, inducing differentiation, and inducing replication stress in a cancer cell. The present disclosure also provides methods for treating a cancer in a patient. Various methods of the disclosure include contacting a cancer cell with, or administering to a patient having cancer, an agent that can change the internal baseline ratio of purine:pyrimidine in the cancer cell.