David Edward Tew

US Patent:

20050136491, Jun 23, 2005

Filed:

Dec 15, 2004

Appl. No.:

11/013016

Inventors:

Wenfang Chen - Newark DE, US
Thomas Meek - Wayne PA, US
David Powell - St. Albans, GB
David Tew - Audubon PA, US

International Classification:

G01N033/53
C07K007/08
C07K007/06

US Classification:

435007500, 530324000, 530325000, 530326000, 530327000, 530328000, 530329000, 530330000

Abstract:

Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.

US Patent:

20070190578, Aug 16, 2007

Filed:

Sep 16, 2005

Appl. No.:

11/228077

Inventors:

Wenfang Chen - Newark DE, US
Thomas Meek - Wayne PA, US
David Powell - St. Albans, GB
David Tew - Audubon PA, US

International Classification:

G01N 33/53
C07D 498/02
C07K 5/04

US Classification:

435007500, 530331000, 548304100

Abstract:

Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.

US Patent:

60718994, Jun 6, 2000

Filed:

Sep 30, 1997

Appl. No.:

8/836085

Inventors:

Deirdre Mary Bernadette Hickey - Saffron Walden, GB
Dashyant Dhanak - West Chester PA
Colin Andrew Leach - Roydon, GB
Robert John Ife - Stevenage, GB
David Graham Tew - Audubon PA

Assignee:

SmithKline Beecham p.l.c. - Brentford

International Classification:

C07D20509
A61K 31395

US Classification:

514210

Abstract:

Azetidinone derivatives of formula (I) in which R. sup. 1 and R. sup. 2, which may be the same or different, is each selected from hydrogen or C. sub. (1-8) alkyl; R. sup. 3 is C. sub. (1-8) alkyl or C. sub. (3-8) cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; and n is 0, 1 or 2; and excluding benzyl (4-methylthio-2-oxo-azetidin-1-yl)acetate are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.

US Patent:

59901020, Nov 23, 1999

Filed:

Nov 21, 1997

Appl. No.:

8/860162

Inventors:

Deirdre Mary Bernadette Hickey - Saffron Walden, GB
Dashyant Dhanak - West Chester PA
Colin Andrew Leach - Hertfordshire, GB
Robert John Ife - Hertfordshire, GB
David Graham Tew - Audubon PA

Assignee:

SmithKline Beecham p.l.c. - Brentford

International Classification:

A61K 31395
C07D20509

US Classification:

514210

Abstract:

Compounds of formula (I) in which R. sup. 1 and R. sup. 2, which may be the same or different, is each selected from hydrogen, halogen or C. sub. (1-8) alkyl; R. sup. 3 is aryl or aryl C. sub. (1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA. sub. 2 and thereof of use in treating atherosclerosis.