David W Threadgill

US Patent:

8323987, Dec 4, 2012

Filed:

Feb 17, 2005

Appl. No.:

10/584960

Inventors:

David Threadgill - Chapel Hill NC, US
Daekee Lee - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12Q 1/00
G01N 33/53
G01N 33/536
G01N 33/537
G01N 33/539
G01N 33/541
C12N 5/00
C12N 5/02
C12N 5/06
C12N 5/16

US Classification:

436538

Abstract:

Provided is a method for screening a plurality of compounds for an ability to bind to a heterodimer of EGFR and another ERBB family member. Also provided are compounds that bind to heterodimers of EGFR and another ERBB family member, and methods of using the identified compounds to suppress the growth of a tumor associated with EGFR heterodimer activity in a subject.

US Patent:

20020123058, Sep 5, 2002

Filed:

Nov 30, 2001

Appl. No.:

09/998058

Inventors:

David Threadgill - Chapel Hill NC, US
Robert Williams - Memphis TN, US

International Classification:

C12Q001/68
A01K067/027

US Classification:

435/006000, 800/018000

Abstract:

A novel population for genetic mapping, methods for generating the disclosed population, and methods for using the disclosed population for efficient identification of genetic loci that modulate a phenotype. Also provided are methods for identifying interactions between genetic loci and non-genetic factors that modulate a phenotype. Further provided are methods for defining epistatic relationships among genes gene networks and non-genetic factors.

US Patent:

20040033596, Feb 19, 2004

Filed:

May 2, 2003

Appl. No.:

10/428977

Inventors:

David Threadgill - Chapel Hill NC, US
Daekee Lee - Chapel Hill NC, US

International Classification:

C12N005/08
C12N005/04

US Classification:

435/325000, 435/366000, 435/419000

Abstract:

Cellular libraries useful for in vitro phenotyping and gene mapping. In a representative approach, a method for preparing a homozygous cellular library includes the steps of providing a heterozygous cellular library comprising a plurality of isolated parent cells; inducing site-specific mitotic recombination in the plurality of isolated parent cells; culturing the plurality of isolated parent cells, whereby a population of daughter cells is produced; and selecting daughter cells comprising a homozygous genetic modification, whereby a homozygous cellular library is prepared.

US Patent:

20090202529, Aug 13, 2009

Filed:

Jul 14, 2006

Appl. No.:

11/887014

Inventors:

David Threadgill - Chapel Hill NC, US
Cordelia Johnson Barrick - Chapel Hill NC, US

International Classification:

A61K 39/395
A61K 31/7088
C12Q 1/48
A01K 67/027

US Classification:

4241331, 435 15, 800 3

Abstract:

Methods of treating or preventing obesity or obesity related disorders in a subject are provided, comprising administering to the subject a treatment effective in reducing one or more activities of an epidermal growth factor receptor (EGFR) in the subject. Methods of screening for compositions that can modulate one or more EGFR activities are also provided.