David J Warner

US Patent:

20110003012, Jan 6, 2011

Filed:

Sep 8, 2008

Appl. No.:

12/677336

Inventors:

Jonathan S. Stamler - Chapel Hill NC, US
David S. Warner - Durham NC, US
James D. Reynolds - Durham NC, US
Huaxin Sheng - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

A61K 33/26
A61K 31/04
A61K 33/00
A61K 31/198
A61P 7/04

US Classification:

424646, 514740, 424718, 514562

Abstract:

A method for attenuating vasoconstriction in a patient with subarachnoid hemorrhage by administering to the patient a therapeutically effective amount of a compound which mediates an increase of bioactive nitric oxide in blood or tissue in the subarachnoid space to cause vasodilation in cerebral, carotid and basilar arteries after the administration of the compound, and wherein the administration of the compound does not reduce mean arterial blood pressure by more than 10%.

US Patent:

20120065181, Mar 15, 2012

Filed:

May 26, 2010

Appl. No.:

13/322072

Inventors:

David S. Warner - Chapel Hill NC, US
Ines Batinic-Haberle - Durham NC, US
Huaxin Sheng - Chapel Hill NC, US
Ivan Spasojevic - Durham NC, US

International Classification:

A61K 31/555
A61P 25/00
A61P 7/04
A61P 9/10

US Classification:

514185

Abstract:

Described herein are methods of treating ischemic injury comprising administering to a subject in need thereof a therapeutically effective amount of a substituted porphyrin compound. Also disclosed are methods of providing neuroprotection, methods of treating subarachnoid hemorrhage, methods of treating traumatic brain injury and methods of treating spinal cord injury using substituted porphyrins.

US Patent:

20130046010, Feb 21, 2013

Filed:

Apr 15, 2011

Appl. No.:

13/641639

Inventors:

Wulf Paschen - Durham NC, US
Wei Yang - Cary NC, US
Huaxin Sheng - Chapel Hill NC, US
David S. Warner - Chapel Hill NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

A61K 31/713
G01N 33/574
A61P 35/00
C12N 5/09
A61K 31/7105
C12Q 1/68
C40B 30/04

US Classification:

514 44 A, 435 612, 436501, 435 611, 435 792, 435 71, 506 9, 435 74, 435375, 514 44 R

Abstract:

Disclosed herein are methods relating to inhibiting or reducing proliferation of a cancer cell, for treating cancer in a subject in need of treatment, predicting the risk of progression of cancer to a more aggressive cancer, and screening for cancer in a subject, that comprise detecting and/or decreasing the levels of SUMO conjugated proteins and detecting and/or interfering with SUMO conjugation.

US Patent:

51484323, Sep 15, 1992

Filed:

Sep 3, 1991

Appl. No.:

7/758393

Inventors:

David W. Gordon - Boulder CO
David C. Stallmo - Boulder CO
David M. Warner - Boulder CO
William A. Brant - Boulder CO
Walter A. Hubis - Louisville CO

Assignee:

Array Technology Corporation - Boulder CO

International Classification:

G06F 1110
G06F 1120

US Classification:

371 101

Abstract:

An arrayed disk drive system for providing memory to a computer, said arrayed system having a plurality of disk drives configured to form an array, said arrayed disk drives accessed by a plurality of channels, each channel accessing a plurality of disk drives, including a means for controlling the logical configuration of the arrayed disk drives to appear to the computer as any conceivable arrangement of disk drives, whereby the arrayed disk drive may appear to the computer as the plurality of disk drives, or as one large disk drive comprised of all the arrayed disk drives, or any combination in between. A means for providing a plurality of levels of redundancy on data read or written by the computer to the arrayed disk drives is provided, as well as means controlled by the controlling means for enabling from none to the plurality of levels of redundancy to operate on data being read or written from the arrayed disk drives.

US Patent:

20180353516, Dec 13, 2018

Filed:

Aug 21, 2018

Appl. No.:

16/107295

Inventors:

- Durham NC, US
- Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
David S. Warner - Chapel Hill NC, US
Kimberly C. Stone - Greenwood Village CO, US
James D. Crapo - Englewood CO, US

International Classification:

A61K 31/555
A61K 9/00
A61K 31/4188

Abstract:

A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.

US Patent:

20160324868, Nov 10, 2016

Filed:

Jan 21, 2015

Appl. No.:

15/109164

Inventors:

- Durham NC, US
- Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
David S. Warner - Chapel Hill NC, US
Kimberly C. Stone - Greenwood Village CO, US
James D. Crapo - Englewood CO, US

International Classification:

A61K 31/555
A61K 9/00

Abstract:

A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.

US Patent:

20150111830, Apr 23, 2015

Filed:

Oct 20, 2014

Appl. No.:

14/519000

Inventors:

- Durham NC, US
Mihai V. Podgoreanu - Chapel Hill NC, US
Qing Ma - Durham NC, US
David S. Warner - Chapel Hill NC, US
Mark F. Newman - Durham NC, US

International Classification:

A61K 38/17

US Classification:

514 164, 514 186, 514 189, 435375

Abstract:

The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an ANXA1 peptide.

Address:

3014 Bear Oak Ln, Cary, NC 27519

VIN:

JTHCE1KS0B0029552

Make:

LEXUS

Model:

GS 350

Year:

2011

Address:

19102 C St, Omaha, NE 68130

VIN:

1HGCM66517A086383

Make:

Honda

Model:

Accord

Year:

2007