David J Weitz

US Patent:

20140065234, Mar 6, 2014

Filed:

Aug 14, 2013

Appl. No.:

13/967018

Inventors:

Ho Cheung Shum - Hong Kong, CN
Daeyeon Lee - Wynnewood PA, US
Insun Yoon - Belmont MA, US
David A. Weitz - Bolton MA, US
Jin-Woong Kim - Gyeonggi-do, KR

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 47/34
A61K 9/16

US Classification:

424501, 525437, 525434, 5147721

Abstract:

The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture. Yet other aspects of the invention are generally directed to methods of making such vesicles, kits involving such vesicles, or the like.

US Patent:

6831741, Dec 14, 2004

Filed:

Aug 22, 2001

Appl. No.:

09/647684

Inventors:

Cornelis Gijsbertus De Kruif - Woudenberg, NL
Erik Ten Grotenhuis - Ede, NL
David Allan Weitz - New Hope PA
Goro Nishimura - Sapporo, JP
Arjun Gaurang Yodh - Merion PA

Assignee:

Stichting Nederlands Instituut voor Zuivelonderzoek (NIZO) - Ba Ede

International Classification:

G01N 2100

US Classification:

356338, 356337

Abstract:

Arrangement for measuring physico-chemical properties of liquid, such as solutions, dispersions and emulsions. The arrangement comprises a light source for producing and emitting light in the liquid, a detector for detecting said light after being scattered by said liquid, processing means arranged for receiving an output signal from said detector. The processing means is further arranged to calculate a maximum value of the mean square displacement r from the autocorrelation function g as a function of time and the value of the property from said calculated maximum value of the mean square displacement r.