David R Weitz

US Patent:

20150079115, Mar 19, 2015

Filed:

Sep 16, 2014

Appl. No.:

14/487592

Inventors:

- Baltimore MD, US
Jeffrey S. Lin - Silver Spring MD, US
Kellogg Schwab - Bel Air MD, US
Timothy Julian - Baltimore MD, US
Christiane Wobus - Dexter MI, US
David Weitz - Bolton MA, US
David Heyman - Somerville MA, US

International Classification:

A61K 39/44
A23L 1/30
A61K 47/48

US Classification:

4241781, 435 5

Abstract:

Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection.

US Patent:

20150024378, Jan 22, 2015

Filed:

Jul 15, 2014

Appl. No.:

14/331714

Inventors:

- Baltimore MD, US
Jeffrey S. Lin - Silver Spring MD, US
David Weitz - Bolton MA, US
Assaf Rotem - Cambridge MA, US

International Classification:

C12Q 1/68

US Classification:

435 5, 435 611

Abstract:

Methods for analyzing DNA-containing samples are provided. The methods can comprise isolating a single genomic equivalent of DNA from the DNA-containing sample to provide a single isolated DNA molecule. The single isolated DNA molecule can be subjected to amplification conditions in the presence of one or more sets of unique molecularly tagged primers to provide one or more amplicons. Any spurious allelic sequences generated during the amplification process are tagged with an identical molecular tag. The methods can also include a step of determining the sequence of the one or more amplicons, in which the majority sequence for each code is selected as the sequence of the single original encapsulated target. The DNA-containing sample can be a forensic sample (e.g., mixed contributor sample), a fetal genetic screening sample, or a biological cell.