David R Willcox

US Patent:

7351833, Apr 1, 2008

Filed:

Jul 7, 2005

Appl. No.:

11/176088

Inventors:

Gregory S. Wayne - Vernon Hills IL, US
Sean M. Mellican - Gurnee IL, US
Geoff G. Z. Zhang - Libertyville IL, US
David R. Willcox - Ridgefield CT, US
Jeffrey M. Breting - Evanston IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 487/04

US Classification:

5462767

Abstract:

The present invention relates to the salt (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3. 2. 0]heptane benzenesulfonate and to methods of preparing the salt.

US Patent:

7498444, Mar 3, 2009

Filed:

Aug 14, 2007

Appl. No.:

11/838713

Inventors:

Gregory S. Wayne - Vernon Hills IL, US
Sean M. Mellican - Gurnee IL, US
Geoff G. Z. Zhang - Libertyville IL, US
David R. Willcox - Ridgefield CT, US
Jeffrey M. Breting - Evanston IL, US

Assignee:

Abboott Laboratories - Abbott Park IL

International Classification:

C07D 487/04

US Classification:

5462767

Abstract:

The present invention relates to the salt (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3. 2. 0]heptane benzenesulfonate and to methods of preparing the salt.

US Patent:

7902371, Mar 8, 2011

Filed:

Jan 23, 2009

Appl. No.:

12/358631

Inventors:

Gregory S. Wayne - Vernon Hills IL, US
Sean M. Mellican - Gurnee IL, US
Geoff G. Z. Zhang - Libertyville IL, US
David R. Willcox - Ridgefield CT, US
Jeffrey M. Breting - Evanston IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 487/04

US Classification:

5462767

Abstract:

The present invention relates to the salt (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3. 2. 0]heptane benzenesulfonate and to methods of preparing the salt.

US Patent:

20130266538, Oct 10, 2013

Filed:

Mar 11, 2013

Appl. No.:

13/794380

Inventors:

Ales Medek - Winchester MA, US
Lori Ann Ferris - Medford MA, US
Praveen Mudunuri - Waltham MA, US
Young Chun Jung - Lexington MA, US
David Richard Willcox - Wellesley MA, US
Michael Waldo - Grafton MA, US
William Aloysius Nugent - Manomet MA, US

International Classification:

C07H 19/10
A61K 45/06
A61K 31/7072

US Classification:

424 857, 536 268, 514 51, 424 854

Abstract:

The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.

US Patent:

20160318969, Nov 3, 2016

Filed:

Jul 14, 2016

Appl. No.:

15/210509

Inventors:

- South San Francisco CA, US
Ales Medek - Winchester MA, US
Lori Ann Ferris - Medford MA, US
Praveen Mudunuri - Waltham MA, US
Young Chun Jung - Lexington MA, US
David Richard Willcox - Wellesley MA, US
Michael Waldo - Grafton MA, US
William Aloysius Nugent - Manomet MA, US

International Classification:

C07H 19/10
A61K 45/06
A61K 31/7072

Abstract:

The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.

US Patent:

20150175647, Jun 25, 2015

Filed:

Dec 22, 2014

Appl. No.:

14/578883

Inventors:

- SOUTH SAN FRANCISCO CA, US
Ales Medek - Winchester MA, US
Lori Ann Ferris - Medford MA, US
Praveen Mudunuri - Waltham MA, US
Young Chun Jung - Lexington MA, US
David Richard Willcox - Wellesley MA, US
Michael Waldo - Grafton MA, US
William Aloysius Nugent - Manomet MA, US

International Classification:

C07H 19/10
A61K 45/06
A61K 31/7072

Abstract:

The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.

US Patent:

20140235703, Aug 21, 2014

Filed:

Jan 24, 2014

Appl. No.:

14/162997

Inventors:

- Boston MA, US
David Willcox - Wellesley MA, US
Stefanie Roeper - Medford MA, US
Kan-Nian Hu - Brighton MA, US
Hoa Q. Luong - Newton MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Boston MA

International Classification:

C07D 333/40

US Classification:

514447, 549 69, 435184

Abstract:

Polymorph Forms M, H, P, X, and ZA of Compound (1) represented by the following structural formula:are described. A method of preparing polymorph Form M of Compound (1) includes stirring a mixture of Compound (1) and a solvent system that includes isopropanol, ethyl acetate, n-butyl acetate, methyl acetate, acetone, 2-butanone (methylethylketone (MEK)), or heptane, or a combination thereof at a temperature in a range of 10 C. to 47 C. to form From M of Compound (1). A method of preparing polymorph Form H of Compound (1) includes stirring a solution of Compound (1) at a temperature in a range of 48 C. to 70 C. to form Form H of Compound (1). A method of preparing polymorph Form P of Compound (1) includes stirring a mixture of Compound (1) and a solvent system that includes a solvent selected from the group consisting of dichloromethane and tetrahydrofuran (THF), and a mixture thereof at room temperature to form Form P of Compound (1). A method of preparing polymorph Form X of Compound (1) includes removing ethyl acetate from ethylacetate solvate G of Compound (1). A method of preparing polymorph Form ZA of Compound (1) includes removing n-butyl acetate from n-butyl acetate solvate A of Compound (1).

US Patent:

20140206888, Jul 24, 2014

Filed:

Jan 24, 2014

Appl. No.:

14/163036

Inventors:

- Boston MA, US
Piero L. Ruggiero - Cambridge MA, US
Stefanie Roeper - Medford MA, US
David Willcox - Wellesley MA, US
Michael Waldo - Grafton MA, US
Dahrika Milfred Yap Guerette - Cambridge MA, US
Billie J. Kline - Kingston MA, US
Hoa Q. Luong - Newton MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Boston MA

International Classification:

C07D 409/12
C07D 333/40

US Classification:

549 60, 549 69

Abstract:

A method of preparing Compound (1):or a pharmaceutically acceptable salt thereof includes: a) reacting Compound (A) with 3,3-dimethylbut-1-yne in the presence of one or more palladium catalysts selected from the group consisting of Pd(PPh)and Pd(PPh)Cl, and one or more copper catalysts selected from the group consisting of CuI, CuBr, and CuCl, to generate Compound (B); b) treating Compound (B) with an acid to generate Compound (C): c) reducing the cyclohexanone of Compound (C) to cyclohexanol to generate Compound (D); and d) reacting Compound (D) with a base to generate Compound (1), wherein Compounds (A), (B), (C), and (D) are each as depicted herein.