David L Wolf

US Patent:

20030207796, Nov 6, 2003

Filed:

Apr 3, 2003

Appl. No.:

10/407098

Inventors:

Uma Sinha - San Francisco CA, US
David Wolf - Davis CA, US

Assignee:

Millennium Pharmaceuticals, Inc.

International Classification:

A61K038/17
A61K039/395

US Classification:

514/008000, 424/145100

Abstract:

Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an 2-6 linkage are able to inhibit the conversion of human Factor X to human Factor Xa. These reagents (SA/Gal/GalNAc binding reagents) as well as other strategies for inhibiting the conversion of Factor X to Factor Xa are useful in treating thrombosis, inflammation and other conditions associated with excess thrombin activity.

US Patent:

56354819, Jun 3, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/467339

Inventors:

David Wolf - Palo Alto CA

Assignee:

COR Therapeutics, Inc. - South San Francisco CA

International Classification:

A61K 3836
A61K 3516
C07K 1447
C07K 14745

US Classification:

514 12

Abstract:

Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.

US Patent:

59900792, Nov 23, 1999

Filed:

Jan 30, 1998

Appl. No.:

9/016400

Inventors:

David L. Wolf - Palo Alto CA
Uma Sinha - San Francisco CA

Assignee:

COR Therapeutics Inc. - South San Francisco CA

International Classification:

A61K 3836
A61K 3516
A61F 1300
C07K 14435

US Classification:

514 2

Abstract:

Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition, modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilia conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.

US Patent:

54967244, Mar 5, 1996

Filed:

May 24, 1993

Appl. No.:

8/067139

Inventors:

Robert M. Scarborough - Belmont CA
David L. Wolf - Palo Alto CA
Israel F. Charo - Lafayette CA

Assignee:

COR Therapeutics, Inc. - South San Francisco CA

International Classification:

C12N 121
C12N 1571
C12N 119
C12N 1512

US Classification:

4352523

Abstract:

An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R. sup. 1. sub. 2 N(CH. sub. 2). sub. 4 CHNHCO-- wherein each R. sup. 1 is independently H, alkyl(1-6C) or at most one R. sup. 1 is R. sup. 2 --C. dbd. NR. sup. 3 wherein R. sup. 2 is H, alkyl(1-6C) or is NR. sup. 4. sub.

US Patent:

56503148, Jul 22, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/470807

Inventors:

David Wolf - Palo Alto CA

Assignee:

COR Therapeutics, Inc. - South San Francisco CA

International Classification:

C12N 950
C12N 120
C12P 2106
C07H 2104

US Classification:

435219

Abstract:

Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.

US Patent:

58916520, Apr 6, 1999

Filed:

Jun 2, 1995

Appl. No.:

8/460490

Inventors:

David Wolf - Palo Alto CA
James E. Tomlinson - San Francisco CA
Larry J. Fretto - Belmont CA
Neill A. Giese - San Francisco CA
Jaime A. Escobedo - San Francisco CA
Lewis Thomas Williams - Tiburon CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 3350

US Classification:

435 721

Abstract:

Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

US Patent:

52781445, Jan 11, 1994

Filed:

Sep 4, 1990

Appl. No.:

7/578646

Inventors:

David Wolf - Palo Alto CA

Assignee:

Cor Therapeutics, Inc. - South San Francisco CA

International Classification:

C07K 710
A61K 3702

US Classification:

514 12

Abstract:

Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.

US Patent:

57705640, Jun 23, 1998

Filed:

Jun 5, 1995

Appl. No.:

8/465178

Inventors:

Robert M. Scarborough - Belmont CA
David Lawrence Wolf - Palo Alto CA
Israel F. Charo - Lafayette CA

Assignee:

COR Therapeutics, Inc. - South San Francisco CA

International Classification:

A61K 3800
A61K 3802
C07K 500
C07K 700

US Classification:

514 9

Abstract:

An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* a modified lysyl residue of the formula R. sup. 1. sub. 2 N(CH. sub. 2). sub. 4 CHNHCO-- wherein each R. sup. 1 is independently H, alkyl(1-6 C) or at most one R. sup. 1 is R. sup. 2 --C. dbd. NR. sup. 3 wherein R. sup. 2 is H, alkyl(1-6 C), phenyl or benzyl, or is NR. sup. 4. sub.

Address:

1142 Surrey Rdg Ln, Robinson, TX 76706

Phone:

(254)7725900

VIN:

2GTEC19J181124521

Make:

GMC

Model:

SIERRA 1500

Year:

2008