David Scott Zaccardelli

US Patent:

20090081319, Mar 26, 2009

Filed:

Nov 24, 2008

Appl. No.:

12/276707

Inventors:

Roger Jeffs - Chapel Hill NC, US
David Zaccardelli - Cary NC, US

International Classification:

A01N 59/00
A61K 31/192
A01P 1/00
A01N 37/44

US Classification:

424722, 514569, 514561

Abstract:

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

US Patent:

20110144204, Jun 16, 2011

Filed:

Feb 7, 2011

Appl. No.:

13/022005

Inventors:

Roger Jeffs - Chapel Hill NC, US
David Zaccardelli - Cary NC, US

International Classification:

A61K 31/192
A01N 37/44
A61K 31/198
A01P 1/00
A01P 3/00
A61P 31/00
A61P 9/12
A61P 31/04
A61P 31/10

US Classification:

514561, 514569

Abstract:

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

US Patent:

20130274340, Oct 17, 2013

Filed:

Jun 7, 2013

Appl. No.:

13/912753

Inventors:

David Zaccardelli - Cary NC, US

International Classification:

A61K 47/18

US Classification:

514569

Abstract:

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

US Patent:

20140194520, Jul 10, 2014

Filed:

Jan 17, 2014

Appl. No.:

14/158091

Inventors:

- Silver Spring MD, US
David Zaccardelli - Cary NC, US

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 47/18

US Classification:

514569

Abstract:

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.