Dawn M Bell

US Patent:

20110288043, Nov 24, 2011

Filed:

May 13, 2009

Appl. No.:

12/990332

Inventors:

Lisa Ruderman Chen - Rye NY, US
Simona Skerjanec - Pittstown NJ, US
Dawn Bell - Morristown NJ, US
Steven Steinhubl - Lexington KY, US

International Classification:

A61K 31/7076
A61P 7/02

US Classification:

514 47

Abstract:

A method of treating or preventing a disease or condition in a subject that was previously treated with at least one thienopyhdine is described. The method includes administering to the subject an effective amount of at least one reversible, short-acting P2Yi2 inhibitor. The described method can be used for subjects diagnosed with symptoms such as stable or unstable angina, vascular ischemic events, atherosclerosis, acute coronary syndrome, as well as STEMi or N-STEMI. The described method can also be used for patients having previously received a stent, such as a bare metal stent or a drug-eluting stent, and the treatment or prevention of stent thrombosis. The method can be used prior to, during, or after an invasive procedure such as coronary artery bypass grafting, percutaneous coronary intervention, or other genera! surgical procedure.

US Patent:

20120141468, Jun 7, 2012

Filed:

Aug 12, 2011

Appl. No.:

13/209271

Inventors:

Lisa Ruderman Chen - Rye NY, US
Simon Skerjanec - Pittstown NY, US
Dawn Bell - Morristown NJ, US
Jayne Prats - Carlisle MA, US
Meredith Todd - Hoboken NJ, US

International Classification:

A61K 39/395
A61K 38/48
A61P 7/02
A61K 38/55
A61K 38/12
A61K 31/7076
A61K 38/49

US Classification:

4241331, 514 47, 424 9467, 424 9464, 514 148, 514 139

Abstract:

A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding.