Deborah Rea Bryan

US Patent:

43872395, Jun 7, 1983

Filed:

Dec 22, 1981

Appl. No.:

6/333850

Inventors:

John G. Gleason - Delran NJ
Charles M. Kinzig - Merion Station PA
Deborah L. Bryan - West Chester PA

Assignee:

SmithKline Beckman Corporation - Philadelphia PA

International Classification:

C07D30342

US Classification:

549562

Abstract:

Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A. 9-oxo-5,6-trans-epoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.

US Patent:

44409397, Apr 3, 1984

Filed:

Nov 4, 1982

Appl. No.:

6/439088

Inventors:

John G. Gleason - Delran NJ
Charles M. Kinzig - Merion Station PA
Deborah L. Bryan - West Chester PA

Assignee:

SmithKline Beckman Corporation - Philadelphia PA

International Classification:

C07D30342

US Classification:

549548

Abstract:

Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.

US Patent:

43527574, Oct 5, 1982

Filed:

Feb 2, 1981

Appl. No.:

6/230915

Inventors:

John G. Gleason - Delran NJ
Charles M. Kinzig - Merion Station PA
Deborah L. Bryan - West Chester PA

Assignee:

SmithKline Beckman Corporation - Philadelphia PA

International Classification:

C07D30342
C07D30340

US Classification:

549513

Abstract:

Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-transepoxyheptanoates, are disclosed.