Deborah L Dean

US Patent:

8309102, Nov 13, 2012

Filed:

May 11, 2011

Appl. No.:

13/105676

Inventors:

Randall J. Mrsny - Los Altos Hills CA, US
Deborah Dean - San Anselmo CA, US

Assignee:

Children's Hospital and Research Center at Oakland - Oakland CA

International Classification:

A61K 39/118
C12P 21/04

US Classification:

4242631, 4241921, 435 697

Abstract:

The present invention relates, in part, to methods and compositions for immunizing against infection by. The methods and compositions rely, in part, on administering an immunogenic composition comprising one or more peptides derived from major outer membrane protein (MOMP) to a subject to be immunized. In some embodiments, the compositions comprise a chimeric immunogens, expression vectors comprising the polynucleotides, and kits comprising the compositions are also provided.

US Patent:

8486411, Jul 16, 2013

Filed:

Aug 29, 2006

Appl. No.:

12/064327

Inventors:

Deborah Dean - Oakland CA, US

Assignee:

Children's Hospital & Research Center at Oakland - Oakland CA

International Classification:

A61K 39/00
A61K 39/02
C07K 1/00
C07K 2/00

US Classification:

4241851, 4241901, 4241921, 4242341, 530300, 530350

Abstract:

The present invention provides a method of classifying an epitope displayed by a polypeptide; a method of determining the presence of an epitope on a polypeptide encoded by a test nucleotide sequence; and a method of generating a nucleotide sequence encoding a polypeptide that exhibits a selected epitope. The present invention provides antigenic polypeptides that display selected epitope(s); chimeric macromolecules comprising such polypeptides; and compositions comprising the antigenic polypeptides or chimeric macromolecules. The present invention further provides methods of inducing an immune response to a. The present invention further provides arrays of nucleic acids, arrays of polypeptides, and arrays of antibodies, which arrays are useful in identification and/or classification of a.

US Patent:

20090214570, Aug 27, 2009

Filed:

May 17, 2006

Appl. No.:

11/914734

Inventors:

Randall J. Mrsny - Los Altos Hills CA, US
Deborah Dean - San Anselmo CA, US

Assignee:

Trinity Biosystems, Inc. - Menlo Park CA
Children's Hospital & Research Center at Oakland - Oakland CA

International Classification:

A61K 39/395
C07K 14/00
C07K 16/00
C07K 14/475
C07K 14/54
C07H 21/00
C07K 7/08
A61P 31/04
A61P 37/04
C07K 7/06
C07K 14/295
C12N 15/63
C12N 1/00
C12P 21/00
A61K 39/118

US Classification:

4241641, 530350, 5303911, 530399, 530351, 536 234, 4353201, 435243, 435 693, 4241921, 530324, 530328, 530326, 530327

Abstract:

The present invention relates, in part, to methods and compositions for immunizing against infection by . The methods and compositions rely, in part, on administering an immunogenic composition comprising one or more peptides derived from major outer membrane protein (MOMP) to a subject to be immunized. In some embodiments, the compositions comprise a chimeric immunogen comprising a receptor binding domain, a translocation domain, and a antigen. Polynucleotides encoding the chimeric immunogens, expression vectors comprising the polynucleotides, and kits comprising the compositions are also provided.