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ISLN:
917326798
Admitted:
2002
University:
Nova Southeastern University, M.S.
Law School:
Barry University Dwayne O. Andreas School of Law, 2002; Barry University School of Law, J.D.
Name / Title
Company / Classification
Phones & Addresses
Deborah Higgins Principal
RUBYSTONE LLC Nonclassifiable Establishments
1736 E Brill St, Phoenix, AZ 85006 5020 Redstone Dr, San Jose, CA 95124
Stephen P. Anderson - San Mateo CA Deborah L. Higgins - San Mateo CA Adair J. Hotchkiss - Half Moon Bay CA Cara B. Marks - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 1558 C12N 1500
US Classification:
435226
Abstract:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
Deborah L. Higgins - San Mateo CA William E. Holmes - Pacifica CA Adair J. Hotchkiss - Half Moon Bay CA
Assignee:
Genentech, Inc. - S. San Francisco CA
International Classification:
A61K 37547 C12N 950 C12N 964
US Classification:
424 9464
Abstract:
Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-file of natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.
Stephen P. Anderson - San Mateo CA Deborah L. Higgins - San Mateo CA Adair J. Hotchkiss - Half Moon Bay CA Cara B. Marks - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 964 C12N 1500 C12N 948 C12N 972
US Classification:
435226
Abstract:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
Deborah L. Higgins - San Mateo CA William E. Holmes - Pacifica CA Adair J. Hotchkiss - Half Moon Bay CA
Assignee:
Genentech, Inc. - San Francisco CA
International Classification:
A61K 37547 C12N 1558 C12N 964
US Classification:
424 9464
Abstract:
Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-life to natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.
Stephen P. Anderson - San Mateo CA Deborah L. Higgins - San Mateo CA Adair J. Hotchkiss - Half Moon Bay CA Cara B. Marks - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 964 C12N 1500 C12N 1558
US Classification:
435226
Abstract:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
Stephen P. Anderson - San Mateo CA Deborah L. Higgins - San Mateo CA Adair J. Hotchkiss - Half Moon Bay CA Cara B. Marks - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 964 C12N 948 C12N 972
US Classification:
435226
Abstract:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
My wife Deborah adores this band, says ATP founder Barry Hogan, who has been organizing ATP events with his wife Deborah Higgins since 2004. When we first started dating she would always say we had to get the Afghan Whigs to play for us. I used to love going to see them. They always sounded great