Deborah B Nelson

US Patent:

20150320753, Nov 12, 2015

Filed:

Feb 17, 2015

Appl. No.:

14/623799

Inventors:

- Roscoff, FR
- Chicago IL, US
Hervé GALONS - Paris, FR
Vladimir RIAZANSKI - Clarendon Hills IL, US
Deborah NELSON - Riverside IL, US

International Classification:

A61K 31/52
G01N 33/50
A61K 45/06

Abstract:

A method for treatment of disease by reduction in macrophages-mediated bacterial killing, including administration to patients in need a compound of formula (I):wherein A is N or CH; B is NO, or S; Ris H, (C-C)alkyl group, methyl(C-C)cycloalkyl group or (C-C)cycloalkyl group; Ris an aryl, arylmethyl group or methylheteroaryl group as methylpyridine and methylthiophene; Ris absent when B is O or S, or is H or (C-C)alkyl group when B is N; Ris (C-C)alkyl group or (C-C)cycloalkyl group, groups bearing a carboxylic acid group, and (C-C)alkyl group or (C-C)cycloalkyl substituted by hydroxyl group, halogen group or methoxy group, when B is N, Rand Rcan together form a 5- or 6-membered heterocycle substituted by carboxylic acid group, substituted by a halogen atom, hydroxyl group, methoxy group or hydroxymethyl group, or pharmaceutically acceptable salt. Also provided are new compounds relating to this use.