Debra Denise Alexander

US Patent:

55996779, Feb 4, 1997

Filed:

Dec 29, 1993

Appl. No.:

8/174964

Inventors:

Barry L. Dowell - Mundelein IL
Carol A. King - Highland Park IL
Debra B. Alexander - Gurnee IL
Allan H. Smith - Zion IL
Susan B. O'Morchoe - Woodridge IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33543
G01N 33573
G01N 33574
G01N 33577

US Classification:

435 74

Abstract:

The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and. alpha. -antichymotrypsin (ACT) that can be used as a calibrator or control in an immunoassay for PSA. Further presented is a method for fractionating polyclonal antibodies, to PSA, into those which bind epitopes that are masked by the binding of PSA to ACT and those which do not bind such epitopes.

US Patent:

56724802, Sep 30, 1997

Filed:

May 23, 1995

Appl. No.:

8/447576

Inventors:

Barry L. Dowell - Mundelein IL
Debra B. Alexander - Gurnee IL
Susan B. O'Morchoe - Woodridge IL
Carol A. King - Highland Park IL
Allan H. Smith - Zion IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33531
G01N 33573

US Classification:

435 74

Abstract:

The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and. alpha. -antichymotrypsin (ACT) that can be used as a calibrator or control in an immunoassay for PSA. Further presented is a method for fractionating polyclonal antibodies, to PSA, into those which bind epitopes that are masked by the binding of PSA to ACT and those which do not bind such epitopes.