Debra G Gilbertson

US Patent:

6468543, Oct 22, 2002

Filed:

Mar 31, 2000

Appl. No.:

09/540224

Inventors:

Debra G. Gilbertson - Seattle WA
Charles E. Hart - Woodinville WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 3818

US Classification:

4241981, 514 2, 530350, 530399, 424484

Abstract:

Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.

US Patent:

6495668, Dec 17, 2002

Filed:

May 3, 2000

Appl. No.:

09/564595

Inventors:

Teresa Gilbert - Seattle WA
Charles E. Hart - Woodinville WA
Paul O. Sheppard - Granite Falls WA
Debra G. Gilbertson - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 3824

US Classification:

530399, 435 694, 435 701, 530350, 536 234

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

6528050, Mar 4, 2003

Filed:

Nov 6, 2000

Appl. No.:

09/706968

Inventors:

Zeren Gao - Redmond WA
Charles E. Hart - Woodinville WA
Christopher S. Piddington - Thousand Oaks CA
Paul O. Sheppard - Granite Falls WA
Kimberly E. Shoemaker - Bellevue WA
Debra G. Gilbertson - Seattle WA
James W. West - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 4500

US Classification:

424 851, 4241981, 530351, 530399

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

6630142, Oct 7, 2003

Filed:

Mar 14, 2001

Appl. No.:

09/808972

Inventors:

Charles E. Hart - Woodinville WA
Stavros Topouzis - Seattle WA
Debra G. Gilbertson - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 39395

US Classification:

4241451, 4241301, 4241331, 4241391, 4241401, 5303871

Abstract:

Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.

US Patent:

6663870, Dec 16, 2003

Filed:

Mar 29, 2001

Appl. No.:

09/823033

Inventors:

Charles E. Hart - Woodinville WA
Debra G. Gilbertson - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 3818

US Classification:

4241981, 530350, 435325

Abstract:

Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.

US Patent:

6814965, Nov 9, 2004

Filed:

May 2, 2002

Appl. No.:

10/139583

Inventors:

Zeren Gao - Redmond WA
Charles E. Hart - Woodinville WA
Christopher S. Piddington - Thousand Oaks CA
Paul O. Sheppard - Granite Falls WA
Kimberly E. Shoemaker - Bellevue WA
Debra G. Gilbertson - Seattle WA
James W. West - Seattle WA

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 39395

US Classification:

4241331, 4241351, 4241391, 4241411, 530351

Abstract:

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

US Patent:

6866991, Mar 15, 2005

Filed:

Aug 23, 2002

Appl. No.:

10/226559

Inventors:

Debra G. Gilbertson - Seattle WA, US
Charles E. Hart - Woodinville WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A01N001/02
A01K038/00
C07K014/00

US Classification:

435 11, 514 2, 530350, 530399

Abstract:

Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.

US Patent:

6893637, May 17, 2005

Filed:

Oct 23, 2000

Appl. No.:

09/695121

Inventors:

Debra G. Gilbertson - Seattle WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K039/395

US Classification:

4241331, 4241351, 4241391, 4241411, 530351

Abstract:

Materials and Methods for treating fibrosis in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf3 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Zvegf3 antagonists include anti-zvegf3 antibodies, mitogenically inactive receptor-binding zvegf3 variant polypeptides, and inhibitory polynucleotides. Within one embodiment of the fibrosis is liver fibrosis.