Debra M Mills

US Patent:

20130331456, Dec 12, 2013

Filed:

Sep 13, 2011

Appl. No.:

13/821682

Inventors:

Arnab Basu - Acton MA, US
Debra M. Mills - Ayer MA, US
John D. Williams - Watertown MA, US
Bing Li - Northborough MA, US
Norton P. Peet - North Andover MA, US
Terry L. Bowlin - Maineville OH, US

International Classification:

C07C 311/44

US Classification:

514604

Abstract:

The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.

US Patent:

20120189614, Jul 26, 2012

Filed:

Jul 10, 2010

Appl. No.:

13/383345

Inventors:

Arnab Basu - Newton Lower Falls MA, US
Debra M. Mills - Ayer MA, US
Norton P. Peet - North Andover MA, US
John D. Williams - Worcester MA, US

Assignee:

Crobiotix, Inc. - Worcester MA

International Classification:

A61K 31/4706
C07C 255/40
C07D 491/22
C07D 405/06
C07D 307/72
C07D 471/04
C07D 243/12
C07D 213/74
C07C 317/50
C07D 249/12
A61P 31/14
A61P 25/00
A61P 37/04
A61P 35/00
A61K 39/395
A61K 38/18
A61P 25/20
A61K 31/277
A61K 31/4375
A61K 31/517
A61K 31/345
A61K 31/437
A61K 31/551
A61K 31/4406
A61K 31/167
A61K 31/4196
C07D 215/40

US Classification:

4241301, 546171, 558405, 546 48, 544290, 549482, 546113, 540567, 546304, 564162, 5482644, 514311, 514 77, 514525, 514283, 51426624, 514472, 514300, 514221, 514352, 514618, 514384

Abstract:

Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.

US Patent:

20190292165, Sep 26, 2019

Filed:

Dec 5, 2017

Appl. No.:

16/348033

Inventors:

- Worcester MA, US
- Bronx NY, US
- Fort Detrick MD, US
John M. Dye - Frederick MD, US
John D. Williams - Fulton MD, US
Zachary D. Aron - Acton MA, US
Jay P. Barbor - Worcester MA, US
Kelly N. Lively - Holliston MA, US
Peter J. Nash - Newton MA, US
Debra M. Mills - Francestown NH, US
Arnab Basu - Acton MA, US

Assignee:

Microbiotix, Inc. - Worcester MA
Albert Einstein College Of Medicine, Inc. - Bronx NY
The Govermnment Of The United States As Represented By The Secretary Of The Army - Fort Detrick MD

International Classification:

C07D 401/04
A61P 31/14
C07D 403/04
C07D 401/14

Abstract:

The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GP) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.