Delwood C Collins

US Patent:

54341850, Jul 18, 1995

Filed:

May 17, 1993

Appl. No.:

8/061477

Inventors:

Delwood C. Collins - Lexington KY
Antonio Gagliardi - Lexington KY
Anjan Bhattacharyya - Lexington KY

Assignee:

The University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 3119

US Classification:

514570

Abstract:

Aurintricarboxylic acid has potent anti-angiogenic activity and may be used for new therapeutic approaches for diseases of neovascularization including the treatment of solid tumors, diabetic retinopathy and arthritis, among others.

US Patent:

57212260, Feb 24, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/478763

Inventors:

Leah L. Frye - Ravena NY
Michael A. Zasloff - Merion Station PA
William A. Kinney - Churchill PA
Robert Moriarty - Oak Park IL
Delwood C. Collins - Lexington KY

Assignee:

Magainin Pharmaceuticals Inc. - Plymouth Meeting PA

International Classification:

A61K 3156
A61K 3157
A61K 3158
A61K 31575

US Classification:

514169

Abstract:

A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a compound according to the following Formula (III) (or a pharmaceutically acceptable salt thereof) can be administered: ##STR1## wherein Z. sub. 5 is. alpha. -H or. beta. -H; each of the substituents Z. sub. 7 is selected from the group of --H, --OH, --SH, --NH. sub. 2, --F, --(C. sub. 1 -C. sub. 3)-alkyl, and --(C. sub. 1 -C. sub. 3)-alkoxy; and one of the substituents Z. sub. 12 is --H and the other is --H or --OH. X' is a polyamine side chain of the formula --X. sub. 1 --(CH. sub. 2). sub. p --X. sub. 2 --(CH. sub. 2). sub. q --N(R. sup. II)(R. sup. III), wherein one of X. sub. 1 and X. sub. 2 is --N(R. sup.

US Patent:

60967307, Aug 1, 2000

Filed:

Jul 23, 1998

Appl. No.:

9/121124

Inventors:

Delwood C. Collins - Lexington KY
Antonio R. Gagliardi - Lexington KY
Peter Nickel - Bonn, DE

Assignee:

University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 3342

US Classification:

514107

Abstract:

Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.

US Patent:

57338990, Mar 31, 1998

Filed:

Apr 20, 1995

Appl. No.:

8/416883

Inventors:

Leah L. Frye - Ravena NY
Michael A. Zasloff - Merion Station PA
William A. Kinney - Churchill PA
Robert Moriarty - Oak Park IL
Delwood C. Collins - Lexington KY

Assignee:

Magainin Pharmaceuticals Inc. - Plymouth Meeting PA

International Classification:

A61K 3156
A61K 3158

US Classification:

514169

Abstract:

A method of treating a bacterial or fungal infection in a patient by administering an effective amount of a compound of Formula (III): ##STR1## wherein, the substituents are as defined in the specification.

US Patent:

61601667, Dec 12, 2000

Filed:

Jul 21, 1999

Appl. No.:

9/357925

Inventors:

Delwood C. Collins - Lexington KY
Antonio R. Gagliardi - Lexington KY
Peter Nickel - Bonn, DE

Assignee:

The University of Kentucky Research Foundation - Lexington KY

International Classification:

C07F 938

US Classification:

562 16

Abstract:

Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.